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首页> 外文期刊>Cellular Physiology and Biochemistry >Sex-Dependent Decrease of Sphingomyelinase Activity During Alcohol Withdrawal Treatment
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Sex-Dependent Decrease of Sphingomyelinase Activity During Alcohol Withdrawal Treatment

机译：戒酒治疗过程中鞘磷脂酶活性的性别依赖性降低

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biBackground /i/biIn vitro/i and iin vivo/i studies have demonstrated the role of the acid sphingomyelinase (ASM) in pathophysiological processes and alterations in response to ethanol exposure. Cellular and plasmatic ASM activities are increased in male alcohol dependent patients and decrease during physical withdrawal. biMethods /i/bHere, we analyzed the time course of ASM in male and also female acutely intoxicated patients during alcohol withdrawal and compared the activity levels to those under long-term maintenance treatment. Craving and further psychometric parameters were assessed by questionnaires. biResults /i/bThe gradual decrease of serum ASM was confirmed in males (p0.001) and continued to lower activities in long-term patients (p=0.001). The trend was similar in females (p=0.178), although the initial enzyme activities were significantly lower (p=0.035). ASM activity strongly correlated with the body mass index in males. The initial ASM activity and its decline during the first two days were associated with the improvement in scores for the Beck depression inventory, the obsessive compulsive drinking and the withdrawal syndrome scales. biConclusion /i/bThese data support the potential of ASM as a biomarker for the course of withdrawal therapy in males and provide the first associations of this enzyme with psychological variables such as craving and depression.
机译：背景 体外和体内研究表明，酸性鞘磷脂酶（ASM）在病理生理过程和乙醇暴露引起的变化。男性酒精依赖患者的细胞和血浆ASM活性增加，而物理戒断期间则降低。 方法 在这里，我们分析了戒酒期间男性和女性急性中毒患者ASM的时程，并将其活动水平与长期维持治疗的患者进行比较。渴望和进一步的心理参数通过问卷进行评估。 结果 在男性中，血清ASM逐渐降低（p <0.001），而长期患者的血清ASM继续降低（p = 0.001）。尽管初始酶活性明显较低（p = 0.035），但女性的趋势相似（p = 0.178）。 ASM活性与男性体重指数密切相关。最初的ASM活动及其在前两天的下降与Beck抑郁量表，强迫性饮酒和戒断综合症量表的得分改善有关。 结论 这些数据支持ASM作为男性戒断治疗过程中生物标志物的潜力，并提供该酶与心理变量（如渴望和沮丧）的首次关联。

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