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首页> 外文期刊>Cellular Physiology and Biochemistry >Ursolic Acid Improves Liver Transplantation and Inhibits Apoptosis in Miniature Pigs Using Donation After Cardiac Death
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Ursolic Acid Improves Liver Transplantation and Inhibits Apoptosis in Miniature Pigs Using Donation After Cardiac Death

机译：熊果酸通过心脏死亡后的捐赠改善肝脏移植并抑制微型猪的凋亡

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>Background: Ursolic acid (UA) possesses extensive pharmacological activities, including anti-oxidation, anti-infection, anti-inflammation, anti-tumor, liver protection. This study was designed to investigate the effect of UA on liver transplantation after liver transplantation using donation after cardiac death (DCD), and to assess the mechanisms. Methods: 24 healthy experimental pigs were randomly divided into control and experimental groups. Each group received six DCD liver transplantations. In the experimental group, the recipient pigs received 120 mg/kg UA 4 h before surgery by intraperitoneal injection. The liver tissues and vein blood were collected 0 h, 1 h, 3 h, 6 h, 12 h and 24 h after transplantation. Morphological change, malondialdehyde (MDA) level, protein kinase-like ER kinase (PERK)-CHOP signaling pathway and apoptosis in liver tissue and serum aminotransferase (ALT) level were assessed. Results: Compared with control group, ALT level was significantly decreased (P<0.05) and pathological changes in liver were ameliorated in experimental group. UA treatment also decreased MDA level in liver tissue and attenuated the apoptosis. Compared with control group, Bax decreased and Bcl-2 increased in UA-treated group. Importantly, UA decreased p-PERK, PERK, p-eIF2?±, eIF2?±, ATF4 and CHOP levels compared with control group. Conclusion: Our results showed that UA treatment could improve the DCD liver transplantation likely through inhibiting apoptosis and PERK-CHOP pathway.
机译：> 背景： 熊果酸（UA）具有广泛的药理活性，包括抗氧化，抗感染，抗炎，抗肿瘤，保护肝脏。本研究旨在通过心源性死亡后捐献（DCD）研究UA对肝移植后UA移植肝的影响，并评估其机制。 方法： 将24只健康实验猪随机分为对照组和实验组。每组接受六次DCD肝移植。在实验组中，接受手术的猪在手术前4小时通过腹膜内注射接受120 mg / kg UA。移植后0 h，1 h，3 h，6 h，12 h和24 h收集肝组织和静脉血。评估形态学变化，丙二醛（MDA）水平，蛋白激酶样ER激酶（PERK）-CHOP信号通路以及肝组织凋亡和血清氨基转移酶（ALT）水平。 结果： 与对照组相比，实验组的ALT水平明显降低（P <0.05），肝脏的病理改变得到改善。 UA治疗还降低了肝组织中的MDA水平并减弱了细胞凋亡。与对照组相比，UA治疗组Bax降低，Bcl-2升高。重要的是，与对照组相比，UA降低了p-PERK，PERK，p-eIF2α±，eIF2α±，ATF4和CHOP水平。 结论： 我们的研究结果表明，UA治疗可能通过抑制细胞凋亡和PERK-CHOP途径来改善DCD肝移植。

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