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首页> 外文期刊>Cellular Physiology and Biochemistry >A Molecular Signature of Two Long Non-Coding RNAs in Peripheral Blood Predicts Acute Renal Allograft Rejection
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A Molecular Signature of Two Long Non-Coding RNAs in Peripheral Blood Predicts Acute Renal Allograft Rejection

机译：外周血中两个长的非编码RNA的分子签名预测急性肾移植排斥反应。

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>Background/Aims: Acute rejection (AR) is a major complication post renal transplantation, with no widely-accepted non-invasive biomarker. This study aimed to explore the expression profiles of long non-coding RNAs (lncRNAs) in the peripheral blood (PB) of renal transplant recipients and their potential diagnostic values. Methods: The genome-wide lncRNA expression profiles were analyzed in 150 PB samples from pediatric and adult renal transplant (PRTx and ARTx) cohorts. The diagnostic performance of differentially expressed lncRNA was determined using receiver operator characteristic curve, with area under the curve (AUC) and 95% confidential interval (CI). Finally, a risk score was constructed with logistical regression model. Results: A total of 162 lncRNAs were found differentially expressed in PRTx cohort, while 163 in ARTx cohort. Among these identified lncRNAs, 23 deregulated accordingly in both cohorts, and could distinguish AR recipients from those without AR. Finally, a risk score with two most significant lncRNAs (AF264622 and AB209021) was generated and exhibited excellent diagnostic performance in both PRTx (AUC:0.829, 95% CI:0.735-0.922) and ARTx cohorts (AUC: 0.889, 95% CI: 0.817-0.960). Conclusion: A molecular signature of two lncRNAs in PB could serve as a novel non-invasive biomarker for the diagnosis of AR in both pediatric and adult renal transplant recipients.
机译：> 背景/目的： 急性排斥反应（AR）是肾移植术后的主要并发症，没有被广泛接受的非侵入性生物标志物。这项研究旨在探讨肾移植受体外周血（PB）中长非编码RNA（lncRNA）的表达谱及其潜在诊断价值。 方法： 在来自儿童和成人肾脏移植（PRTx和ARTx）队列的150 PB样本中分析了全基因组lncRNA表达谱。差异表达的lncRNA的诊断性能使用接收者操作员特征曲线确定，曲线下面积（AUC）和95％机密区间（CI）。最后，采用逻辑回归模型构建风险评分。 结果： 在PRTx队列中共发现162个lncRNA差异表达，而在ARTx队列中则有163个mRNA差异表达。在这些鉴定出的lncRNA中，两个队列中相应地解除了调控，有23种可以将AR受体与没有AR的受体区分开。最后，在PRTx（AUC：0.829，95％CI：0.735-0.922）和ARTx组（AUC：0.889，95％CI：PRTx）中产生了具有两个最重要的lncRNA（AF264622和AB209021）的风险评分，并表现出出色的诊断性能。 0.817-0.960）。 结论： PB中两个lncRNA的分子标记可以作为一种新颖的非侵入性生物标记物，用于诊断小儿和成人肾移植受者的AR。

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