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首页> 外文期刊>Cellular Physiology and Biochemistry >Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention
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Atherosclerosis and the Hydrogen Sulfide Signaling Pathway - Therapeutic Approaches to Disease Prevention

机译：动脉粥样硬化和硫化氢信号传导途径-疾病预防的治疗方法

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>Hydrogen sulfide (H2S) is now admitted as a third gasotransmitter together with nitric oxide (NO) and carbon monoxide (CO), albeit it was originally considered as a foul and poisonous gas. Endogenous H2S production in mammalian cells is counting on the three enzymes acting on cysteine. Involvement of H2S in various physiological and pathological processes has been extensively studied in the last fifteen years. Mounting evidence suggests that H2S is able to protect against atherosclerosis development and progression. Exogenous H2S supplement has salutary effects on atherogenesis, and reduction of the endogenous H2S level accelerates atherosclerosis. The anti-atherosclerotic mechanisms of H2S have been descried in different aspects, including endothelium preservation, antioxidative action, anti-inflammatory responses, vasorelaxation, regulation of ion channels, etc. However, further investigation is still needed to help us gain more insights into the fundamental underlying mechanisms, and that will allow us to design better therapeutic applications of H2S in the treatment of atherosclerosis.
机译：>硫化氢（H 2 S）与一氧化氮（NO）和一氧化碳（CO）一起被认为是第三种气体传输剂，尽管最初被认为是恶臭和有毒气体。哺乳动物细胞中内源性H 2 S的产生依赖于作用于半胱氨酸的三种酶。在过去的十五年中，已经广泛研究了H 2 S在各种生理和病理过程中的参与。越来越多的证据表明，H 2 S能够预防动脉粥样硬化的发生和发展。外源性H 2 S补充剂对动脉粥样硬化具有有益的作用，内源性H 2 S水平的降低会加速动脉粥样硬化。 H 2 S的抗动脉粥样硬化机制已在不同方面进行了描述，包括内皮保存，抗氧化作用，抗炎反应，血管舒张，离子通道调节等。然而，仍需进一步研究需要帮助我们深入了解基本的潜在机制，这将使我们能够设计更好的H 2 S在动脉粥样硬化治疗中的应用。

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