Upregulation of Na+-coupled Glucose transporter SGLT1 by Tau Tubulin Kinase 2

Ioana Alesutan; Mentor Sopjani; Miribane D?rmaku-Sopjani; Carlos Munoz; Jakob Voelkl; Florian Lang

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Upregulation of Na+-coupled Glucose transporter SGLT1 by Tau Tubulin Kinase 2

机译：Tau微管蛋白激酶2对Na +偶联的葡萄糖转运蛋白SGLT1的上调。

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The Tau-tubulin-kinase 2 (TTBK2) is a serine/threonine kinase expressed in various tissues including tumors. Up-regulation of TTBK2 increases resistance of tumor cells against antiangiogenic treatment and confers cell survival. Tumor cell survival critically depends on cellular uptake of glucose, which is partially accomplished by SGLT1 (SLC5A1) mediated Nasup+/sup-coupled glucose transport. The present study explored whether TTBK2 participates in the regulation of SGLT1 activity. To this end, electrogenic glucose transport was determined in iXenopus /ioocytes expressing SGLT1 with or without wild-type TTBK2, truncated TTBK2sup[1-450]/sup or kinase inactive mutants TTBK2-KD and TTBK2-KDsup[1-450]/sup. TTBK2, but not TTBK2sup[1-450]/sup, TTBK2-KD or TTBK2-KDsup[1-450]/sup, increased membrane carrier protein abundance and electrogenic glucose transport capacity in SGLT1-expressing iXenopus /ioocytes. Thus TTBK2 is a completely novel regulator of Nasup+/sup-coupled glucose transport.

机译：Tau-tubulin-kinase 2（TTBK2）是在包括肿瘤在内的各种组织中表达的丝氨酸/苏氨酸激酶。 TTBK2的上调增加了肿瘤细胞对抗血管生成治疗的抵抗力，并赋予了细胞生存能力。肿瘤细胞的存活关键取决于细胞对葡萄糖的摄取，这部分是通过SGLT1（SLC5A1）介导的Na + 偶联的葡萄糖转运来完成的。本研究探讨了TTBK2是否参与SGLT1活性的调节。为此，在表达有或没有野生型TTBK2，截短的TTBK2 [1-450] 或激酶无活性突变体TTBK2-KD的爪蟾卵母细胞中确定了生葡萄糖的转运和TTBK2-KD [1-450] 。 TTBK2，而不是TTBK2 [1-450] ，TTBK2-KD或TTBK2-KD [1-450] ，增加了SGLT1的膜载体蛋白丰度和电葡萄糖转运能力-表达非洲爪蟾卵母细胞。因此，TTBK2是Na + 偶联葡萄糖转运的全新调节剂。

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来源
《Cellular Physiology and Biochemistry》 |2012年第2期|共8页
作者
Ioana Alesutan; Mentor Sopjani; Miribane D?rmaku-Sopjani; Carlos Munoz; Jakob Voelkl; Florian Lang;
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中图分类细胞生物物理学;
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Glucose carrierTumor cellsKinaseElectrophysiology;

机译：葡萄糖载体肿瘤细胞激酶电生理;

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1. Upregulation of Na ~+-coupled glucose transporter SGLT1 by tau tubulin kinase 2 [J] . Alesutan I., Sopjani M., Drmaku-Sopjani M., Cellular Physiology and Biochemistry . 2013,第2期

机译：牛磺酸微管蛋白激酶2对Na〜+偶联葡萄糖转运蛋白SGLT1的上调
2. Up-regulation of Na+-coupled glucose transporter SGLT1 by caveolin-1 [J] . ElviraB., HonischS., AlmilajiA., Biochimica et biophysica acta. Biomembranes . 2013,第11期

机译：小窝蛋白1对Na +偶联葡萄糖转运蛋白SGLT1的上调
3. Downregulation of Mouse Intestinal Na+-coupled Glucose Transporter SGLT1 by Gum Arabic (Acacia Senegal) [J] . Nasir O, Artunc F, Wang K, Cellular Physiology and Biochemistry . 2010,第2a3期

机译：阿拉伯胶（塞内加尔阿拉伯胶）下调小鼠肠道Na +偶联葡萄糖转运蛋白SGLT1
4. Polymer-Phloridzin Conjugates as an Anti-diabetic Drug that Inhibits Glucose Absorption through the Na~+/Glucose Cotransporter (SGLT1) in the Small Intestine [C] . Y. Ikumi, T. Kida, S. Sakuma, Controlled Release Society Annual Meeting and Exposition . 2007

机译：高分子磷脂结合作为一种抑制糖尿病的药物，通过小肠中的Na〜+ /葡萄糖共转运蛋白（SGLT1）抑制葡萄糖吸收。
5. In vivo characterization of Tau-tubulin kinase 1 in neurocognitive impairment and neurodegeneration. [D] . Xu, Jiqing. 2010

机译：Tau-微管蛋白激酶1在神经认知障碍和神经变性中的体内表征。
6. Rapid Upregulation of Sodium-Glucose Transporter SGLT1 in Response to Intestinal Sweet Taste Stimulation [O] . Adam T. Stearns, Anita Balakrishnan, David B. Rhoads, -1

机译：钠 - 葡萄糖转运sGLT1的快速上调响应肠道甜味刺激
7. Up-regulation of Na+-coupled glucose transporter SGLT1 by caveolin-1 [O] . Elvira, Bernat, Honisch, Sabina, Almilaji, Ahmad, 2013

机译：小窝蛋白1对Na +偶联葡萄糖转运蛋白SGLT1的上调

Upregulation of Na+-coupled Glucose transporter SGLT1 by Tau Tubulin Kinase 2

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