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首页> 外文期刊>Cellular Physiology and Biochemistry >Panax Quinquefolium Saponins Attenuate Myocardial Dysfunction Induced by Chronic Ischemia
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Panax Quinquefolium Saponins Attenuate Myocardial Dysfunction Induced by Chronic Ischemia

机译：人参五倍子皂苷减轻慢性缺血引起的心肌功能障碍

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Background/Aims Previous studies in rat models of myocardial ischemia showed that Panax quinquefolium saponins (PQS) could attenuate ischemic/reperfusion injury, increase vessel density and improve cardiac function. In the current study, we examined whether PQS could attenuate myocardial dysfunction in a swine model of chronic myocardial ischemia (CMI). Methods CMI was established in Bama mini-pigs by placing amroid constrictor on the left anterior descending artery (LAD). Starting from 2 months after the surgery, pigs randomly received PQS (30 mg/kg/day), atorvastatin (1.5 mg/kg/day), or no drug for one month (n=6). A group of pigs receiving sham surgery was included as an additional control. Glucose utilization was assessed with positron emission tomography-computer tomography (PET-CT). Cardiac function was assessed with echocardiography. Myocyte size, nuclear density, and arteriolar density were examined in tissue section obtained from the ischemia area. Potential molecular targets of PQS were identified using proteomic analysis with isobaric tags for relative and absolute quantitation (iTARQ) and network pharmacology. Results In comparison to the sham controls, pigs implanted with ameroid constrictor had decreased ventricular wall motion, left ventricular ejection fraction (LVEF), and glucose utilization. PQS significantly increased cardiac function and glucose utilization. Arteriole density and myocyte nuclear density were increased. Myocyte diameter was decreased. PQS also attenuated the CMI-induced change of protein expression profile. The effects of atorvastatin were generally similar to that of PQS. However, PQS attenuated the reduction of left ventricular systolic WT induced by CMI more robustly than atorvastatin. Conclusion The results from the current study supports the use of PQS in patients with coronary artery disease.
机译：背景/目的先前在大鼠心肌缺血模型中的研究表明，西洋参总皂苷（PQS）可以减轻缺血/再灌注损伤，增加血管密度并改善心脏功能。在当前的研究中，我们检查了PQS是否可以减轻慢性心肌缺血（CMI）猪模型中的心肌功能障碍。方法通过在左前降支动脉（LAD）上放置环形收缩器，在巴马小型猪中建立CMI。从手术后2个月开始，猪随机接受PQS（30 mg / kg /天），阿托伐他汀（1.5 mg / kg /天）或一个月不服药（n = 6）。一组接受假手术的猪作为额外的对照。通过正电子发射断层扫描-计算机断层扫描（PET-CT）评估葡萄糖利用率。通过超声心动图评估心脏功能。在从局部缺血区域获得的组织切片中检查了肌细胞大小，核密度和小动脉密度。 PQS的潜在分子靶标是通过蛋白质组学分析和同量异位标签进行相对和绝对定量（iTARQ）和网络药理学鉴定的。结果与假手术对照组相比，植入类人猿收缩器的猪的心室壁运动，左心室射血分数（LVEF）和葡萄糖利用率均降低。 PQS显着增加心脏功能和葡萄糖利用。小动脉密度和心肌细胞核密度增加。心肌细胞直径减少。 PQS还减弱了CMI诱导的蛋白质表达谱变化。阿托伐他汀的作用通常与PQS相似。然而，与阿托伐他汀相比，PQS更有效地减弱了CMI诱导的左室收缩期WT的降低。结论本研究的结果支持PQS在冠心病患者中的使用。

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