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首页> 外文期刊>Canadian Respiratory Journal >Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography
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Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography

机译：每日慢性间歇性低压低氧不能通过超声心动图评估导致肺动脉压的慢性增加

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Chronic hypoxia causes pulmonary vascular remodeling resulting in persistently increased pulmonary arterial pressures (PAP) even after return to normoxia. Recently, interest in chronic intermittent hypobaric hypoxia (CIHH) was raised because it occurs in subjects working at high altitude (HA) but living in lowland. However, effects of daily CIHH on PAP are unknown. In this pilot study, we included 8 healthy subjects working at (2650?m) each workday for 8-9?h while living and sleeping at LA and 8 matched control subjects living and working at LA. Cardiorespiratory measurements including echocardiography at rest and during exercise were performed at LA (Munich, 530?m) and HA (Zugspitze, 2650?m). Hemoglobin was higher in CIHH subjects. LA echocardiography showed normal right and left cardiac dimensions and function in all subjects. Systolic PAP (sPAP) and tricuspid annular plane systolic excursion (TAPSE) at rest were similar in both groups. Resting blood gas analysis (BGA) at HA revealed decreased pCO2 in CIHH compared to controls (HA 28.4 versus 31.7?mmHg, ). During exercise, sPAP was lower in CIHH subjects compared to controls (LA 28.7 versus 35.3?mmHg, ; HA 26.3 versus 33.6?mmHg, ) and peripheral oxygen saturation (SpO2) was higher. In sum, subjects exposed to CIHH showed no signs of pulmonary vascular remodeling.
机译：慢性缺氧会导致肺血管重构，甚至在恢复常氧后也会导致肺动脉压（PAP）持续升高。最近，人们对慢性间歇性低压缺氧（CIHH）产生了兴趣，因为它发生在高海拔（HA）工作但生活在低地的受试者中。但是，每日CIHH对PAP的影响尚不清楚。在这项先导研究中，我们纳入了8位健康受试者，每个工作日在（2650？m）上在洛杉矶生活和睡眠，工作时间为8-9？h，以及8位相匹配的对照受试者在洛杉矶生活和工作。分别在LA（慕尼黑，530？m）和HA（楚格峰，2650？m）进行心脏呼吸测量，包括静息和运动过程中的超声心动图检查。在CIHH受试者中血红蛋白较高。 LA超声心动图显示所有受试者的正常左右心脏尺寸和功能。两组的静止期收缩压PAP（sPAP）和三尖瓣环平面收缩期偏移（TAPSE）相似。 HA的静息血气分析（BGA）显示，与对照组相比，CIHH中的pCO2降低（HA 28.4对31.7？mmHg，）。运动期间，CIHH受试者的sPAP低于对照组（LA 28.7对35.3？mmHg; HA 26.3对33.6？mmHg，），外周血氧饱和度（SpO2）较高。总之，暴露于CIHH的受试者没有显示出肺血管重构的迹象。

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