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首页> 外文期刊>Canadian Respiratory Journal >Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease
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Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease

机译：呼气时间：慢性阻塞性肺疾病中呼气胸部CT的附加价值

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Objectives. Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes. The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration. Materials and Methods. Forty-six patients with diagnosed COPD underwent spirometry, body plethysmography, and dose-optimized CT in maximal inspiration and expiration. Four quantified CT parameters were acquired in inspiration, expiration, and their calculated delta values. These parameters were correlated with seven established lung function parameters. Results. For inspiratory scans, a weak-to-moderate correlation with the lung function parameters was found. These correlations significantly improved when adding the expiratory scan (). Moreover, some parameters showed a significant correlation only in expiratory datasets. Calculated delta values showed even stronger correlation with lung function testing. Conclusions. Expiratory quantified CT and calculated delta values significantly improve the correlation with lung function parameters. Thus, an additional expiratory CT may improve image-based phenotyping of patients with COPD.
机译：目标。慢性阻塞性肺疾病（COPD）的诊断指南基于肺量测定法和临床标准。但是，这不能充分解决疾病的病理生理复杂性。到目前为止，吸气式胸部计算机断层扫描（CT）被认为是这些患者的首选影像学方法。我们假设呼气CT可能更能证明病理生理变化。这项前瞻性研究的目的是系统地比较肺功能测试和定量CT参数在吸气和呼气中的作用。材料和方法。 46例确诊为COPD的患者在最大吸气和呼气时接受了肺量计，人体体积描记法和剂量优化的CT检查。在吸气，呼气及其计算的增量值中获取了四个量化的CT参数。这些参数与七个已建立的肺功能参数相关。结果。对于吸气扫描，发现与肺功能参数之间存在弱到中等的相关性。添加呼气扫描（）时，这些相关性显着改善。此外，某些参数仅在呼气数据集中显示出显着的相关性。计算出的δ值显示出与肺功能测试的更强相关性。结论。呼气量化的CT和计算的增量值显着改善了与肺功能参数的相关性。因此，额外的呼气CT可以改善COPD患者基于图像的表型。

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