Small Molecule Inhibitors of Acid Sphingomyelinase

Christoph Arenz

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Small Molecule Inhibitors of Acid Sphingomyelinase

机译：酸性鞘磷脂酶的小分子抑制剂

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Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid sphingomyelinase as an emerging drug target. Very recently, some new and promising inhibitors from different substance classes have been developed. In this review, previous and current developments in the field are summarized.

机译：尽管酸性鞘磷脂酶对于鞘磷脂稳态和鞘脂信号传导很重要，但这种酶的有效和选择性抑制剂却很少。使用间接抑制剂在不同疾病模型中抑制酸性鞘磷脂酶的数据越来越多，强烈暗示酸性鞘磷脂酶是新兴的药物靶标。最近，已经开发了一些来自不同物质类别的新的和有希望的抑制剂。在这篇综述中，总结了该领域以前和当前的发展。

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《Cellular Physiology and Biochemistry》 |2010年第1期|共8页
作者
Christoph Arenz;
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中图分类细胞生物物理学;
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1. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro[S] [J] . Journal of Lipid Research . 2020,第6期

机译：小分子ARC39的表征，酸鞘磷脂酶的直接和特异性抑制剂在体外[S]
2. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro [J] . Eyad Naser, Stephanie Kadow, Fabian Schumacher, Journal of Lipid Research . 2020,第6期

机译：小分子ARC39的表征，体外酸鞘氨基氨基酶的直接和特异性抑制剂
3. Small molecule inhibitors of acid sphingomyelinase [J] . Arenz C. Cellular Physiology and Biochemistry . 2010,第1期

机译：酸性鞘磷脂酶的小分子抑制剂
4. DESIGN OF HIGHLY EFFECTIVE CORROSION INHIBITOR MOLECULES FOR ACID CORROSION OF STEEL USING QUANTUM CHEMICAL APPROACH [C] . S. Kholeif, S. Senior, D. Said Annual Conference of the Australasian Corrosion Association . 2014

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5. A Heck-Based Approach to the Synthesis of Anacardic Acids and an Exploration of Its Derivatives as Small-Molecule Inhibitors of the Sumo E1 Enzyme and Aminoalkylation of Adamantanes Using Dual Photoredox-Hat Catalysis [D] . Weigel, William Kenneth, III. 2020

机译：一种基于Heck的嗜酸性酸合成的方法和衍生物作为Sumo E1酶的小分子抑制剂的探索，使用双光毒毒帽催化与氨烷烷的氨基烷基化物
6. Characterization of the small molecule ARC39 a direct and specific inhibitor of acid sphingomyelinase in vitro [O] . Eyad Naser, Stephanie Kadow, Fabian Schumacher, 2020

机译：小分子ARC39的表征它是酸性鞘磷脂酶的直接和特异性抑制剂
7. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro [O] . Eyad Naser, Stephanie Kadow, Fabian Schumacher, 2020

机译：小分子ARC39的表征，体外酸鞘氨基氨基酶的直接和特异性抑制剂

Small Molecule Inhibitors of Acid Sphingomyelinase

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