...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction
【24h】

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

机译：瘤内缺氧的糖生物学修改：糖相互作用的无呼吸面。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

>Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently leading to the establishment and progression of several diseases, including cancer. Furthermore, a growing amount of research has shown that different oxygen tensions, mainly hypoxia, leads to a markedly altered glycosylation, resulting in altered glycan-receptor interactions. Alteration of intracellular glucose metabolism, from aerobic cellular respiration to anaerobic glycolysis, inhibition of integrin 3?±1?2 translocation to the plasma membrane, decreased 1,2-fucosylation of cell-surface glycans, and galectin overexpression are some consequences of the hypoxic tumor microenvironment. Additionally, increased expression of gangliosides carrying N-glycolyl sialic acid can also be significantly affected by hypoxia. For all these reasons, it is possible to realize that hypoxia strongly alters glycobiologic events within tumors, leading to changes in their behavior. This review aims to analyze the complexity and importance of glycoconjugates and their molecular interaction network in the hypoxic context of many solid tumors.
机译：>在蛋白质，脂质和其他碳水化合物中，聚糖的翻译后和共翻译酶促添加（糖基化）是涉及细胞周期，粘附，侵袭和信号转导的分子机制的有力调节剂，通常在体内和体外癌症模型中均可见。糖基转移酶可以改变正常细胞的糖基化模式，从而导致包括癌症在内的几种疾病的发生和发展。此外，越来越多的研究表明，不同的氧气张力（主要是缺氧）会导致糖基化作用显着改变，从而导致聚糖-受体相互作用发生改变。细胞内葡萄糖代谢的变化，从有氧细胞呼吸到厌氧糖酵解，整联蛋白3？±1？2易位到质膜，细胞表面聚糖的1,2-岩藻糖基化减少，以及半乳糖凝集素的过表达是低氧的一些后果。肿瘤微环境。另外，缺氧还可以显着影响携带N-羟乙酸唾液酸的神经节苷脂的表达增加。由于所有这些原因，有可能意识到缺氧会强烈改变肿瘤内的糖生物学事件，从而导致其行为发生变化。这篇综述旨在分析在许多实体瘤缺氧情况下糖缀合物及其分子相互作用网络的复杂性和重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号