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Statins and Thyroid Carcinoma: a Meta-Analysis

机译：他汀类药物和甲状腺癌：荟萃分析

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Background/Aims Experimental studies have reported the antineoplastic effects of statins in thyroid carcinoma; however, observational studies suggested that statins might increase the risk of thyroid carcinoma. Therefore, this study evaluated the antineoplastic effects of statins in both in vitro studies and animal models, as well as the epidemiological evidence. Methods Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries— were searched. A meta-analysis was performed with sufficiently homogeneous studies. Eighteen articles were involved. Results In in vitro studies, statins showed a concentration-dependent inhibition of cell line growth (weighted mean difference –34.68, 95% confidence interval –36.53 to –32.83). A significant efficacy of statin-induced apoptosis was observed (weighted mean difference [95% confidence interval] 24 h, 57.50 [55.98–59.03]; 48 h, 23.43 [22.19–24.66]; 72 h, 51.29 [47.52–55.07]). Early apoptosis was increased in a dose- and time-dependent manner. In in vivo antitumor studies, lovastatin inhibited tumor growth, as shown by a reduction in tumor volume. However, two clinical studies showed discordant results from the experimental studies. Conclusion Experimental studies revealed the antineoplastic efficacy of statins but statins were associated with thyroid carcinoma in clinical studies. This discrepancy may be due to the different concentrations of statins used and the effects of hyperlipidemia interventions, and thus further study is required.
机译：背景/目的实验研究报告了他汀类药物在甲状腺癌中的抗肿瘤作用。但是，观察性研究表明，他汀类药物可能会增加甲状腺癌的风险。因此，本研究评估了他汀类药物在体外研究和动物模型中的抗肿瘤作用，以及流行病学证据。方法检索了PubMed，Cochrane图书馆，SinoMed，CNKI，万方和临床试验注册数据库。进行荟萃分析并进行充分均质的研究。涉及十八篇。结果在体外研究中，他汀类药物显示出浓度依赖性抑制细胞系生长（加权平均差异–34.68，95％置信区间–36.53至–32.83）。观察到他汀类药物诱导的细胞凋亡具有显着疗效（加权平均差异[95％置信区间] 24 h，57.50 [55.98-59.03]; 48 h，23.43 [22.19-24.66]; 72 h，51.29 [47.52-55.07]） 。早期凋亡以剂量和时间依赖性方式增加。在体内抗肿瘤研究中，洛伐他汀抑制肿瘤的生长，如肿瘤体积的减少所表明。但是，两项临床研究显示实验研究结果不一致。结论实验研究表明他汀类药物具有抗肿瘤作用，但在临床研究中他汀类药物与甲状腺癌有关。这种差异可能是由于所用他汀类药物的浓度不同以及高脂血症干预措施的影响，因此需要进一步研究。

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