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首页> 外文期刊>Cell Reports >Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity
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Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

机译：热量限制和饮食引起的体重减轻不会导致肥胖妇女和男性的人皮下白色脂肪组织褐变

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Summary Caloric restriction (CR) is standard lifestyle therapy in?obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8?week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent of changes in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneous abdominal WAT browning in people with obesity.
机译：小结热量限制（CR）是肥胖症管理中的标准生活方式疗法。 CR引起的体重减轻可改善肥胖个体的代谢状况。在小鼠中，在白色脂肪仓库中出现米色脂肪细胞有利于代谢健康的表型，而CR则促进白色脂肪组织（WAT）的褐变。在此，我们对289名肥胖症患者进行了皮下腹部WAT样本分析，该饮食分为两个阶段的饮食干预，包括8周的低热量饮食和6个月的体重维持阶段。干预之前，我们显示出性别差异和季节变化，肥胖女性和冬季女性分别具有较高的棕色和米色标记表达。低热量饮食可减少腹部皮下WAT的褐变。在整个饮食干预过程中，体内脂肪和胰岛素抵抗的演变与棕色和米色脂肪标记的变化无关。这些数据表明，饮食引起的对肥胖症患者体内脂肪和胰岛素抵抗的影响与皮下腹部WAT褐变无关。

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