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首页> 外文期刊>Cells >New Insights into the Interplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in Regulating Cellular Functions
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New Insights into the Interplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in Regulating Cellular Functions

机译：非编码RNA与RNA结合蛋白HnRNPK在调节细胞功能中相互作用的新见解

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The emerging data indicates that non-coding RNAs (ncRNAs) epresent more than the “junk sequences” of the genome. Both miRNAs and long non-coding RNAs (lncRNAs) are involved in fundamental biological processes, and their deregulation may lead to oncogenesis and other diseases. As an important RNA-binding protein (RBP), heterogeneous nuclear ribonucleoprotein K (hnRNPK) is known to regulate gene expression through the RNA-binding domain involved in various pathways, such as transcription, splicing, and translation. HnRNPK is a highly conserved gene that is abundantly expressed in mammalian cells. The interaction of hnRNPK and ncRNAs defines the novel way through which ncRNAs affect the expression of protein-coding genes and form autoregulatory feedback loops. This review summarizes the interactions of hnRNPK and ncRNAs in regulating gene expression at transcriptional and post-transcriptional levels or by changing the genomic structure, highlighting their involvement in carcinogenesis, glucose metabolism, stem cell differentiation, virus infection and other cellular functions. Drawing connections between such discoveries might provide novel targets to control the biological outputs of cells in response to different stimuli.
机译：新兴的数据表明，非编码RNA（ncRNA）的表达超过了基因组的“垃圾序列”。 miRNA和长非编码RNA（lncRNA）都参与基本的生物学过程，其失调可能导致肿瘤发生和其他疾病。作为一种重要的RNA结合蛋白（RBP），异质核糖核蛋白K（hnRNPK）可以通过涉及各种途径（例如转录，剪接和翻译）的RNA结合域来调节基因表达。 HnRNPK是高度保守的基因，在哺乳动物细胞中大量表达。 hnRNPK和ncRNA的相互作用定义了ncRNA影响蛋白质编码基因表达并形成自调节反馈环的新途径。这篇综述总结了hnRNPK和ncRNA在转录和转录后水平或通过改变基因组结构调节基因表达的相互作用，强调了它们参与致癌作用，葡萄糖代谢，干细胞分化，病毒感染和其他细胞功能。在这些发现之间建立联系可能会提供新颖的靶标，以响应不同的刺激来控制细胞的生物学输出。

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