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首页> 外文期刊>Cellular Physiology and Biochemistry >The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population
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The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population

机译：中国汉族男性人群中CARD8 rs2043211多态性与闭塞性动脉硬化易感性的关系

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>Background and aims: Cholesterol crystals have been shown to cause inflammation. As a response to cholesterol crystal accumulation, the NLRP3 inflammasome is activated to produce IL-1?2 which eventually leads to atherosclerotic lesions. As a part of innate immunity, CARD8 is involved in the modulation of above mentioned inflammatory activities. The primary objective of this study was to investigate the association between polymorphism of CARD8 rs2043211 and susceptibility to arteriosclerosis obliterans (ASO) in Chinese Han male population. Methods: 758 male arteriosclerosis obliterans patients and 793 male controls were genotyped for rs2043211 with the TaqMan allele assays. Fasting blood-glucose (FBG), total cholesterol (TC), triglycerides (TG), urea nitrogen, creatinine, Serum uric acid, high density lipoprotein, low density lipoprotein, ALT, AST, and IL-1?2 in the blood were detected for all subjects. Clinical data were recorded to analyze the genotype-phenotype. Independent samples t-test was used to perform the comparisons between two groups. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to measure the strength of relationship in the genotype distribution and allele frequencies between patients and controls. The analysis of variance was used for a genotype-phenotype analysis of the ASO patients. Results: The genotypic and allelic frequencies in the ASO group were significantly different from that in the control group (P = 0.014 by genotype, P = 0.003 by allele). Those carrying the genotype TT had a higher risk for ASO than those carrying the genotype AA (OR = 1.494, 95%CI1.131-1.974, P = 0.005).The difference was also significant after the adjustment for the history of smoking, TC, LDL, fasting blood glucose, systolic blood pressure and BMI(OR = 1.525, 95%CI1.158-2.009, P = 0.003). Conclusion: Our finding suggests that the polymorphism of CARD8 rs2043211 is probably associated with the development of ASO in Chinese Han male population.
机译：> 背景和目的 胆固醇晶体被证明可引起炎症。作为对胆固醇晶体积累的反应，NLRP3炎性小体被激活产生IL-1β2，最终导致动脉粥样硬化病变。作为先天免疫的一部​​分，CARD8参与了上述炎症活动的调节。这项研究的主要目的是调查中国汉族男性人群中CARD8 rs2043211多态性与对闭塞性动脉硬化的敏感性之间的关系。 方法： 采用TaqMan等位基因检测对758名男性闭塞性男性动脉硬化患者和793名男性对照进行rs2043211基因分型。空腹血糖（FBG），总胆固醇（TC），甘油三酸酯（TG），尿素氮，肌酐，血清尿酸，高密度脂蛋白，低密度脂蛋白，ALT，AST和IL-1？2为所有主题检测到。记录临床数据以分析基因型-表型。使用独立样本t检验进行两组之间的比较。计算具有95％置信区间（CI）的几率（OR），以测量患者与对照组之间基因型分布和等位基因频率之间的关系强度。方差分析用于ASO患者的基因型-表型分析。 结果： ASO组的基因型和等位基因频率与对照组有显着差异（基因型P = 0.014，等位基因P = 0.003）。携带TT基因型的人发生ASO的风险高于携带AA基因型的人（OR = 1.494，95％CI1.131-1.974，P = 0.005）。在调整了吸烟史TC后，差异也很显着，低密度脂蛋白（LDL），空腹血糖，收缩压和BMI（OR = 1.525，95％CI1.158-2.009，P = 0.003）。 结论： 我们的发现表明，中国汉族男性人群CARD8 rs2043211的多态性可能与ASO的发生有关。

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