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首页> 外文期刊>Cerebrum: the Dana Forum on Brain Science >Alabama to Beijing... and Back: The Search for a Pain Gene
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Alabama to Beijing... and Back: The Search for a Pain Gene

机译：阿拉巴马州到北京...往返：寻找痛苦的基因

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摘要

P ain—“ it hurts ”—is experienced at some time or another by almost every human being. When pain is transient, it can protect us, warning us to withdraw from a threatening situation. But pain is not always helpful: if it persists when a noxious stimulus is no longer there, it can invade and change a life. This occurs, for example, in people with neuropathic pain due to traumatic nerve injury, peripheral neuropathies associated with diabetes or chemotherapy, and post-herpetic neuralgia. Chronic pain affects more patients than cancer, heart disease, and diabetes combined.SUP1/SUP And it is often unrelieved or only partially relieved by existing medications, whose side-effects may include double-vision, confusion, sleepiness, or gastrointestinal dysfunction. Some of these drugs can be addictive. There is a clear need for more effective pain medications without these drawbacks.
机译：疼痛-“它很疼”-几乎每个人都经历过一段时间。当疼痛短暂时，它可以保护我们，警告我们退出威胁性局势。但是疼痛并不总是有帮助的：如果在有害刺激不再存在时疼痛持续存在，它就会入侵并改变生活。例如，在因外伤性神经损伤导致神经性疼痛，与糖尿病或化学疗法有关的周围神经病以及疱疹后神经痛的人中会发生这种情况。慢性疼痛比癌症，心脏病和糖尿病加起来影响的患者还多。 1 而且，现有药物通常无法缓解或仅部分缓解其疼痛，其副作用可能包括双眼复视，精神错乱，嗜睡，或肠胃功能障碍。其中一些药物可能会上瘾。显然需要没有这些缺点的更有效的止痛药。

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