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首页> 外文期刊>Ceylon Medical Journal >Behavioral, familial and comorbid illness risk factors of colorectal cancer: a case control study
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Behavioral, familial and comorbid illness risk factors of colorectal cancer: a case control study

机译：大肠癌的行为，家族和合并症疾病危险因素：病例对照研究

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IntroductionThough colorectal cancer is a disease of public health importance, there is little evidence about risk factors of colorectal cancer in South Asians.ObjectivesWe aimed to determine the behavioral, familial and comorbid illness risk factors for colorectal cancer among Sri Lankan adults.MethodsWe conducted this study among 325 participants (65 incident colorectal cancer cases, 130 hospital and 130 community controls) in five major health care institutions and communities in areas with high incidence in Sri Lanka. Behavioral, genetic and comorbid risk factors were assessed through an interviewer administered questionnaire. Risk factors were evaluated using bivariate and multivariate logistic regression.ResultsAdjusted logistic regression showed that frequent consumption of red meat (OR 3.06, 95% CI 1.26-7.43) and deep fried food (OR 2.54, 95% CI 1.22-5.39), hypertension ≥ 10 years (OR 3.3, 95% CI 1.3-8.6), colorectal cancer (OR 4.91, 95% CI 1.70-14.18) and other cancers (OR 3.0, 95% CI 1.14-7.81) among first degree relatives and age 50 years (OR 2.6, 95% CI 1.1 to 5.9) were significant risk factors compared to hospital controls. Frequent consumption of deep fried food (OR 4.2, 95% CI 1.7-10.1), being an ever smoker (OR 3.2, 95% CI 1.1-9.3), a current or former drinker (OR 5.4, 95% CI 1.1-27.8) and hypertension ≥ 10 (OR 5.1, 95% CI 1.7-15.6) were risk factors compared to community controls.ConclusionThe behavioral, familial and comorbid illness risk factors identified should be considered in designing preventive strategies and identifying high-risk individuals for screening for colorectal cancer.??.
机译：引言尽管结直肠癌是一种重要的公共卫生疾病，但在南亚人中，结直肠癌的危险因素尚无证据。目的我们旨在确定斯里兰卡成年人中行为，家族和合并症的疾病危险因素。在斯里兰卡高发地区的五个主要卫生保健机构和社区的325名参与者（65名结直肠癌事件，130名医院和130名社区控制人员）中。行为，遗传和合并症危险因素通过访问员管理的问卷进行评估。风险因素采用双因素和多因素logistic回归进行评估。结果经过调整的logistic回归显示，经常食用红肉（OR 3.06，95％CI 1.26-7.43）和油炸食品（OR 2.54，95％CI 1.22-5.39），高血压≥一级亲属中年龄大于50岁的10年（OR 3.3，95％CI 1.3-8.6），结直肠癌（OR 4.91，95％CI 1.70-14.18）和其他癌症（OR 3.0，95％CI 1.14-7.81） （OR 2.6，95％CI 1.1至5.9）与医院对照组相比是重要的危险因素。经常食用油炸食品（OR 4.2，95％CI 1.7-10.1），曾经吸烟者（OR 3.2，95％CI 1.1-9.3），现在或以前的饮酒者（OR 5.4，95％CI 1.1-27.8）与社区对照组相比，高血压和≥10（OR 5.1，95％CI 1.7-15.6）是危险因素。结论在设计预防策略和确定高危人群进行大肠癌筛查时，应考虑所确定的行为，家族和合并症的危险因素癌症。？？。

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