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首页> 外文期刊>Ceylon Medical Journal >Pattern of Rheumatic valvular involvement and its contribution towards valvular malfunction in young adults
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Pattern of Rheumatic valvular involvement and its contribution towards valvular malfunction in young adults

机译：风湿性瓣膜受累模式及其对年轻人瓣膜功能障碍的贡献

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ObjectiveTo study the different patterns of valvular malfunction in Rheumatic heart disease (RHD) and assess the factors contributing towards it.Methods This is an observational study among patients with chronic RHD. One hundred patients (female 81 and 19 males) within ages 12 to 40 years (Mean age 27.3) were analyzed. A relevant clinical history including that of an initial episode of acute rheumatic fever (ARF) and recurrent episodes was obtained. 2D echo assessment of the cardiac valves was performed with an estimation of Wilkins score for the mitral valve (MV).Results Among the study population female: male ratio was 4:1. 30% had recurrent episodes of ARF. Only 60% had at least some evidence of ARF at any time in their life. The posterior mitral valve appears to be affected more than the anterior leaflet giving an average Wilkins score of 9.7 and 6.7 respectively. The total score had a positive correlation with Mitral stenosis (MS) (p 0.05). A regurgitant grade of 2 or more was found in 41%. High sensitive C reactive protein of more than 1mg/dl was noted in 55% of patients. ?ConclusionChronic rheumatic MV disease can exist as MS, MR, MVP or simply an elevated valve score. Apart from recurrent streptococcal infections and chronic sub clinical inflammation, a number of different components of valve damage contribute towards the end result.
机译：目的研究风湿性心脏病（RHD）的瓣膜功能障碍的不同类型，并评估其致病因素。方法这是一项对慢性RHD患者的观察性研究。分析了12到40岁（平均年龄27.3）内的100位患者（女性81位和19位男性）。获得了相关的临床病史，包括急性风湿热（ARF）的初始发作和复发发作。对心脏瓣膜进行二维回声评估，并估计威尔金斯二尖瓣（MV）得分。结果在研究人群中，女性与男性的比例为4：1。 30％复发性ARF。只有60％的人一生中至少在任何时候都有ARF的证据。二尖瓣后部受到的影响似乎要比前小叶受到的影响更大，威尔金斯平均评分分别为9.7和6.7。总分与二尖瓣狭窄（MS）呈正相关（p 0.05）。发现41％的反流等级为2或更高。在55％的患者中发现超过1mg / dl的高敏感性C反应蛋白。结论慢性风湿性MV疾病可以以MS，MR，MVP或单纯瓣膜评分升高的形式存在。除了反复发生的链球菌感染和慢性亚临床炎症外，瓣膜损伤的许多不同成分也有助于最终结果。

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