• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ceylon Medical Journal >Performance of Sri Lankan FRAX algorithm without bone mineral density and with Quantitative Ultrasound data input
【24h】

Performance of Sri Lankan FRAX algorithm without bone mineral density and with Quantitative Ultrasound data input

机译：在没有骨矿物质密度和超声定量数据输入的情况下，斯里兰卡FRAX算法的性能

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction Fracture risk assessment algorithm (FRAX) is the most validated method available to predict fracture risk. Its use is restricted due to limited availability of Dual Energy X-ray Absorptiometry (DXA). FRAX has the option of assessing facture risk without BMD data. ObjectivesTo assess the ability of Sri Lankan FRAX algorithm without BMD input in evaluating fracture risk. The possibility of replacing the BMD input with Quantitative Ultrasound (QUS) data of radius in calculating fracture risk also assessed. MethodsData of clinical risk factors associated with fractures were collected from community dwelling postmenopausal women (n=339). DXA scans were performed in all subjects and QUS scans (in radius) were performed in a randomly selected sample (n=207). Ten-year risks of major osteoporotic fracture (MOFR) and hip fracture (HFR) were calculated with BMD, without BMD (FRAX-FN0) and with US T score instead of BMD (FRAX-UST). Results and conclusionNearly 35.7% had high risk of fractures. FRAX-FN0 had 79.2% sensitivity, 80.1% specificity, 68.8% positive predictive value (PPV) and 87.4% negative predictive value (NPV). FRAX-UST showed 78.4% sensitivity, 70% specificity, 59.8% PPV and 85% NPV. ROC AUCs were above 0.80 in both FRAX-FN0 and FRAX-UST. The standard errors of estimate (SEE) were less in FRAX-FN0 (3.96 and 2.76 for MOFR-FN0 and HFR-FN0 respectively) compared to FRAX-UST (6.13 and 4.83 for MOFR-UST and HFR-UST, respectively). In conclusion, Sri Lankan FRAX without BMD is an acceptable alternative in areas with restricted DXA facility. Radial QUS data cannot be used as a substitute to FN-BMD in Sri Lankan FRAX.
机译：简介骨折风险评估算法（FRAX）是可用于预测骨折风险的最有效方法。由于双能X射线吸收仪（DXA）的可用性有限，其使用受到限制。 FRAX可以选择无需BMD数据即可评估断裂风险。目的评估斯里兰卡没有BMD输入的FRAX算法评估骨折风险的能力。还评估了在计算骨折风险时用半径超声定量（QUS）数据替换BMD输入的可能性。方法从社区居住的绝经后妇女（n = 339）中收集与骨折相关的临床危险因素的数据。在所有受试者中进行DXA扫描，并在随机选择的样本（n = 207）中进行QUS扫描（沿半径）。使用BMD，不使用BMD（FRAX-FN0）和以US T评分代替BMD（FRAX-UST）来计算重大骨质疏松性骨折（MOFR）和髋部骨折（HFR）的十年风险。结果与结论近35.7％的患者发生骨折的风险很高。 FRAX-FN0的敏感性为79.2％，特异性为80.1％，阳性预测值（PPV）为68.8％，阴性预测值（NPV）为87.4％。 FRAX-UST显示出78.4％的敏感性，70％的特异性，59.8％的PPV和85％的NPV。 FRAX-FN0和FRAX-UST的ROC AUC均高于0.80。与FRAX-UST（分别为MOFR-UST和HFR-UST的6.13和4.83）相比，FRAX-FN0的标准估计误差（SEE）较小（MOFR-FN0和HFR-FN0分别为3.96和2.76）。总之，在DXA设备受限的地区，不带BMD的斯里兰卡FRAX是可以接受的替代方案。径向QUS数据不能替代斯里兰卡FRAX中的FN-BMD。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号