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首页> 外文期刊>Case Reports in Infectious Diseases >A Gigantic Anal Mass: Buschke–Löwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome
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A Gigantic Anal Mass: Buschke–Löwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome

机译：巨大的肛门肿块：Buschke–Löwenstein肿瘤在HIV感染控制且致命的患者中

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摘要

Buschke–Löwenstein tumor of anorectal and perianal area is a rare but highly aggressive tumor, frequently associated with human papillomavirus (HPV) types 6 and 11. It often grows over years in immunocompetent patients and can be highly destructive to local tissue. We present a case of a 61-year-old male with HIV infection who presented with worsening pain and swelling in the anorectal area for one-year duration. Exam revealed a 15 × 10 cm mass in the anorectal area with multiple sinuses and fistulas. MRI revealed extension of the mass through pelvic structures. Biopsy showed squamous epithelium with koilocytes and histochemistry positive for P16, suggestive of HPV infection. Biopsy was negative for malignant transformation. He was not a candidate for surgery or radiation due to extensive infiltration of deeper structures and multiple fistulas. He refused interferon therapy, and diverting colostomy was placed for palliation. He presented two months later with overwhelming sepsis and died despite maximal medical therapy.
机译：肛门直肠和肛周区的Buschke-Löwenstein肿瘤是一种罕见但高度侵袭性的肿瘤，通常与6型和11型人类乳头瘤病毒（HPV）有关。它在具有免疫能力的患者中生长数年，并且对局部组织具有高度破坏性。我们提供了一个感染艾滋病毒的61岁男性的病例，该病例在肛门直肠区域持续一年的疼痛和肿胀加剧。检查显示肛门直肠区域有15××10×10 cm的肿块，有多个窦和瘘管。 MRI显示肿块通过骨盆结构扩展。活检显示鳞状上皮中有纤毛细胞，并且P16的组织化学呈阳性，提示HPV感染。活检阴性为恶性转化。由于深层结构和多处瘘管的广泛浸润，他不是手术或放疗的候选人。他拒绝了干扰素治疗，并改行了结肠造瘘术以减轻痛苦。两个月后，他出现败血症，尽管进行了最大程度的药物治疗，他仍然死亡。

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