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首页> 外文期刊>Bangladesh Journal of Medical Science >The Effect of Combination of Quercetin And Glibenclamide on Myocardial Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Expression In Type 2 Diabetic Rat
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The Effect of Combination of Quercetin And Glibenclamide on Myocardial Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Expression In Type 2 Diabetic Rat

机译：槲皮素和格列本脲联合用药对2型糖尿病大鼠心肌核因子红系2相关因子2（Nrf2）表达的影响

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Background. Diabetes mellitus (DM) is a metabolic disorder syndrome that marked by hyperglycemia. The main macrovascular complication is heart failure due to diabetic cardiomyopathy. Hyperglycemia can increase reactive oxygen species (ROS) and lipid peroxidation that induce cellular damage. Quercetin is an antioxidant that reduce hyperglycemia and ROS by modify the expression of nuclear factor erythroid 2-related factor 2 (Nrf 2). Objective. The aim of this research was to investigate the effect of combination of quercetin and glibenclamide on myocardial nuclear factor erythroid 2-related factor 2 (nrf 2) expression in type 2 diabetic rat compared with no combination. Methods. The rats were divided randomly into nine groups (each group consisted of four rats). The control group consist of a normal group that received placebo, DM control groups that received placebo and glibenclamide and intervention groups received quercetin 5, 20 and 80 mg/kgbw/day and combination of quercetin with 5 mg/kgbw/day of glibenclamide orally for a period of four weeks. The expression of myocardial Nrf 2 was measured by immunohistochemistry. Data was analyzed by ANOVA and p<0.05 was considered as significant. Results. Twenty and 80 mg/kgbw/day of quercetin with or without combination with glibenclamide orally for a period of four weeks increase myocardial Nrf2 expression higher than placebo (p<0.05). Eighty mg/kgbw/day of quercetin increase myocardial Nrf2 expression higher than 5 and 20 mg/kgbw/day (p<0.05). Conclusion. From this study it can be suggested that there are significant different in expression level of myocardial Nrf2 of type 2 DM after a combination of quercetin and glibenclamide, quercetin alone, glibenclamide alone and placebo. Bangladesh Journal of Medical Science Vol.16(2) 2017 p.302-306
机译：背景。糖尿病（DM）是一种以高血糖症为特征的代谢紊乱综合征。主要的大血管并发症是由于糖尿病性心肌病引起的心力衰竭。高血糖症会增加活性氧（ROS）和脂质过氧化，从而引起细胞损伤。槲皮素是一种抗氧化剂，可通过修饰核因子红系2相关因子2（Nrf 2）的表达来降低高血糖症和ROS。目的。这项研究的目的是研究槲皮素和格列本脲联合使用对不联合使用对2型糖尿病大鼠心肌核因子红系2相关因子2（nrf 2）表达的影响。方法。将大鼠随机分为九组（每组由四只大鼠组成）。对照组由接受安慰剂的正常组，接受安慰剂和格列本脲的DM对照组，以及接受槲皮素5、20和80 mg / kgbw /天，以及槲皮素与5 mg / kgbw /天的格列本脲口服组合的DM对照组组成。为期四个星期。通过免疫组织化学测量心肌Nrf 2的表达。通过ANOVA分析数据，p ＜0.05被认为是显着的。结果。每天服用20克槲皮素和80毫克/千克体重/天的槲皮素，口服或不口服与格列本脲合用4周，可使心肌Nrf2的表达高于安慰剂（p <0.05）。槲皮素使80 mg / kgbw /天的心肌Nrf2表达增加高于5和20 mg / kgbw /天（p <0.05）。结论。从这项研究可以表明，在槲皮素和格列本脲，单独的槲皮素，单独的格列本脲和安慰剂联合使用后，2型DM心肌Nrf2的表达水平存在显着差异。孟加拉国医学杂志Vol.16（2）2017 p.302-306

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