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Amiodarone-induced pulmonary toxicity

机译：胺碘酮引起的肺毒性

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Amiodarone-induced pulmonary toxicity is a critical and potentially fatal side effect of amiodarone. Our study was designed to reveal its clinical features, including KL-6, as an interstitial marker. The medical records of eight patients (five men and three women) with amiodarone-induced pulmonary toxicity, who had been referred to our hospital, were examined. The mean age at the initiation of amiodarone was 48 years (range, 54-87 years) and mean duration of medication prior to the development of pulmonary toxicity was 18 months (range, 7-33 months). Serum KL-6 was elevated in six of the eight patients with a range of 525-2915 U/mL. Chest computed tomography (CT) findings showed non-segmental consolidation and/or ground glass opacity. Foamy macrophages were found in bronchoalveolar lavage (BAL) fluids of all examined patients and in transbronchial lung biopsy (TBLB) specimens in half of the examined patients. We concluded that serum KL-6, chest CT findings, and foamy macrophages in BAL fluids and TBLB specimens will be helpful for the diagnosis of amiodarone-induced pulmonary toxicity.
机译：胺碘酮引起的肺毒性是胺碘酮的关键和潜在的致命副作用。我们的研究旨在揭示其临床特征，包括KL-6作为间质标记。检查了八名胺碘酮引起的肺毒性患者（五男三女）的病历，这些患者已被转诊至我院。胺碘酮起始的平均年龄为48岁（范围54-87岁），在发生肺毒性之前的平均药物治疗时间为18个月（范围7-33个月）。八名患者中有六名的血清KL-6升高，范围为525-2915 U / mL。胸部计算机断层扫描（CT）结果显示非节段性固结和/或毛玻璃不透明。在所有接受检查的患者的支气管肺泡灌洗液（BAL）和经检查的一半患者的经支气管肺活检（TBLB）标本中均发现泡沫状巨噬细胞。我们得出的结论是，血清KL-6，胸部CT表现以及BAL液和TBLB标本中的泡沫巨噬细胞将有助于诊断胺碘酮诱发的肺毒性。

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