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首页> 外文期刊>CHROMATOGRAPHY >Analysis of Acid Dissociation Equilibrium of Bupropion by Capillary Zone Electrophoresis After the Heat-Degradation
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Analysis of Acid Dissociation Equilibrium of Bupropion by Capillary Zone Electrophoresis After the Heat-Degradation

机译：降解后的毛细管区带电泳分析安非他酮的酸离解平衡

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An acid dissociation constant (pK _(a)) of bupropion has been determined in an aqueous solution by capillary zone electrophoresis (CZE). Electrophoretic mobility of bupropion was measured by CZE over its acid-dissociating pH range, and a pK _(a) value has been determined as 8.75±0.02 (mean ± standard error, ionic strength: 0.010 mol dm~(?3)). Although bupropion degrades under heated and alkaline conditions and the degraded species from bupropion coexist in the aqueous solution, the pK _(a) value of bupropion can also be determined by CZE with the residual bupropion without any interference from the degraded species. The pK _(a) value determined after the heat-degradation was 8.74±0.02; the result agreed well with the one determined with the freshly prepared solution. Utilization of the separation characteristics of CZE has been demonstrated with bupropion for the analysis of the fast equilibrium of acid-base reaction under the coexistence of the degraded species.
机译：已经通过毛细管区带电泳（CZE）在水溶液中确定了安非他酮的酸解离常数（pK_（a））。通过CZE在其酸解离的pH范围内测量安非他酮的电泳迁移率，并且ap K _（a）值已确定为8.75±0.02（平均值±标准误差，离子强度：0.010 mol dm〜（？3） ））。尽管安非他酮在加热和碱性条件下会降解，并且安非他酮的降解物种共存于水溶液中，但安非他酮的p K _（a）值也可以通过CZE测定，残留安非他酮不受降解物种的干扰。热降解后测定的pκ_（a）值为8.74±0.02。结果与刚准备好的溶液确定的结果非常吻合。已证明安非他酮可利用CZE的分离特性分析降解物种共存下酸碱反应的快速平衡。

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