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Molecularly Imprinted Tailor-Made Functional Polymer Receptors for Highly Sensitive and Selective Separation and Detection of Target Molecules

机译:分子印迹量身定制的功能聚合物受体,用于目标分子的高灵敏度和选择性分离与检测

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Molecularly imprinted polymers (MIPs) are functional materials capable of molecular recognition and other biorelevant functions and can be prepared with ease in a tailor-made fashion by copolymerization in the presence of a crosslinker and a template molecule (the target molecule or its analog) conjugated with a functional monomer(s). These robust and affordable synthetic polymer receptors are highly accepted as favorable alternatives to biomacromolecules such as antibodies and enzymes. This article provides a critical review of the present state of MIPs to establish perspectives on this technique via a survey of early to contemporary work, mainly conducted by the authors, covering new principles and methodology to generate MIPs. These include the design and synthesis of new functional monomers and crosslinkers to develop and/or introduce new functionalities, new polymerization methods to improve the imprint effect, and highly sensitive MIP-based assays and sensors.
机译:分子印迹聚合物(MIP)是具有分子识别和其他生物相关功能的功能材料,可以通过在交联剂和共轭的模板分子(目标分子或其类似物)存在下共聚,轻松地以量身定制的方式制备与功能单体结合。这些健壮且价格适中的合成聚合物受体被广泛用作生物大分子(如抗体和酶)的有利替代品。本文对MIP的现状进行了批判性回顾,以通过对作者的早期到当代工作的调查来建立对该技术的观点,主要是由作者进行的,涵盖了生成MIP的新原理和方法。这些包括设计和合成新的功能性单体和交联剂以开发和/或引入新的功能性,新的聚合方法以改善压印效果以及高度敏感的基于MIP的测定和传感器。

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