• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>CHROMATOGRAPHY >Development of Separation Sciences Utilizing the Specific Properties of Microscopic Separation Fields
【24h】

Development of Separation Sciences Utilizing the Specific Properties of Microscopic Separation Fields

机译：利用微观分离场的特殊性质发展分离科学

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This review focuses on researches regarding separation sciences utilizing the specific properties of microscopic separation fields. One of the topics is related to the separation by capillary electrophoresis (CE). Despite of its superior performances, CE still has major problems to be overcome such as non-specific interactions between capillary surfaces and samples, difficulty in fabricating stationary phases inside micrometer-sized capillaries, and its lower sensitivity. Therefore, in this first section, to resolve these problems, our obtained knowledge and developed methods were introduced. By our obtained knowledge and developed methods, following separations were attained; (i) the charge/size separation of cationic particles as cationic species by CE, (ii) an easy fabrication method of stationary phases in micrometer-sized capillaries, which enables high reproducible chiral separations in packed capillary electrochromatography, and (iii) high selective separation and high sensitive detection of proteins with multi-functional particles. In the second section, “Lipid Nanotechnology” for separation sciences was mentioned. “Lipid nanotechnology” is a technique utilizing superior properties of lipid self-assembled structures for separation. For establishment of separation methods with lipid nanotechnology, characterization methods for separation field, lipid self-assembled structures were described. Then, some our results of separation with lipid nanotechnology were introduced, especially emergence of chiral recognition in lipid bilayer by polymerization, the application of lipid self-assembled structures for flow separation systems, and membrane proteins separation in lipid nano-membrane.
机译：这篇综述着重于利用微观分离领域的特殊性质的有关分离科学的研究。主题之一与毛细管电泳（CE）分离有关。尽管具有卓越的性能，CE仍然要克服主要问题，例如毛细管表面和样品之间的非特异性相互作用，在微米级毛细管内部难以制备固定相以及灵敏度较低。因此，在第一部分中，为了解决这些问题，介绍了我们获得的知识和开发的方法。通过我们获得的知识和发达的方法，可以实现以下分离： （i）通过CE对作为阳离子物种的阳离子颗粒进行电荷/尺寸分离，（ii）在微米级毛细管中固定相的简便制造方法，可在填充毛细管电色谱中实现高再现性的手性分离，以及（iii）高选择性具有多功能颗粒的蛋白质的分离和高灵敏度检测。在第二部分中，提到了用于分离科学的“脂质纳米技术”。 “脂质纳米技术”是一种利用脂质自组装结构的优异性能进行分离的技术。为了建立利用脂质纳米技术的分离方法，描述了分离场的表征方法，脂质自组装结构。然后，介绍了我们使用脂质纳米技术进行分离的一些结果，特别是通过聚合在脂质双层中出现手性识别，脂质自组装结构在流动分离系统中的应用以及膜蛋白在脂质纳米膜中的分离。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号