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首页> 外文期刊>Chinese Journal of Biology >Hepatoprotective Effect ofCitrus limonFruit Extract against Carbofuran Induced Toxicity in Wistar Rats
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Hepatoprotective Effect ofCitrus limonFruit Extract against Carbofuran Induced Toxicity in Wistar Rats

机译：柠檬柠檬果提取物对呋喃丹诱导的Wistar大鼠毒性的肝保护作用

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Carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate), is known to induce oxidative stress and to cause inhibition of acetylcholinesterase activity. The present work was envisaged to evaluate the effect of carbofuran on redox indices and its interactions with hepatic markers in rat. The ameliorating effect ofCitrus limonfruit extract on carbofuran induced toxicity was also monitored. The results indicated that carbofuran treatment caused significant alterations in the levels of activities of AST, ALT, and LDH in liver tissues and serum. The levels of enzymatic oxidative stress markers such as SOD and catalase and nonenzymatic redox molecules such as total thiol, GSH, and protein thiol also showed significant perturbations in rat liver due to carbofuran treatment. The administration ofCitrus limonfruit extract, however, was able to markedly ameliorate the toxicity of carbofuran by protecting the levels of aforesaid biomarkers to near normal levels. The ameliorative effect ofCitrus limonfruit extract may be due to the presence of different antioxidants in it which may neutralize the ROS and RNS generated in the body tissue due to pesticide stress. These results suggested thatCitrus limonfruit extract may be utilized as a potential supplement in proper management of pesticide intoxication in association with relevant therapeutics.
机译：已知呋喃丹（2,3-二氢-2,2-二甲基-7-苯并呋喃甲酸甲酯）可引起氧化应激并抑制乙酰胆碱酯酶活性。设想目前的工作是评价呋喃丹对大鼠氧化还原指数的影响及其与肝标志物的相互作用。还监测了柠檬柠檬果提取物对呋喃丹引起的毒性的改善作用。结果表明，呋喃丹治疗引起肝脏组织和血清中AST，ALT和LDH活性水平的显着改变。酶的氧化应激指标（如SOD和过氧化氢酶）和非酶的氧化还原分子（如总硫醇，谷胱甘肽和蛋白质硫醇）的水平也因碳氢呋喃处理而在大鼠肝脏中表现出明显的扰动。然而，柠檬柑桔提取物的施用能够通过将上述生物标志物的水平维持在接近正常水平而显着改善了呋喃丹的毒性。柠檬柠檬果提取物的改善作用可能是由于其中存在不同的抗氧化剂，这些抗氧化剂可以中和由于农药胁迫而在人体组织中产生的ROS和RNS。这些结果表明，柠檬柠檬果提取物可作为与相关治疗方法相结合的农药中毒处理的潜在补充剂。

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