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首页> 外文期刊>Chinese Medicine >Searching Clue of the Relationship between the Alteration of Bioactive Ingredients and the Herbal “Property” Transformation from Raw Rehmanniae Radix (Sheng-Di-Huang) to Steam-Heating-Processed Rehmanniae Radix (Shu-Di-Huang) by Chromatographic Fingerprint Analysis
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Searching Clue of the Relationship between the Alteration of Bioactive Ingredients and the Herbal “Property” Transformation from Raw Rehmanniae Radix (Sheng-Di-Huang) to Steam-Heating-Processed Rehmanniae Radix (Shu-Di-Huang) by Chromatographic Fingerprint Analysis

机译：用色谱指纹图谱分析生地黄生地黄蒸熟地黄的生物活性成分变化与中草药“物产”转化关系的线索

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“Di-Huang” (Rehmanniae Radix) is a peculiar Chinese herbal drug, the fresh root named “Xian-Di-Huang” (“Xian” means fresh; the commerce is now rarely available), mild-baking-dried raw roots “Sheng-Di-Huang” (“Sheng” means raw) and steam-processed “Shu-Di-Huang” (“Shu” implies steam-processed). The both kinds of herbal drug exert different efficiencies with different property according to the traditional clinical theory. It would be of interest that searching the clue of why the therapeutic functions of the same drug differ between the pre- and post-processing. To disclose the comprehensive alteration of the iridoids, saccharides and phenylethanoids occurred between the raw and steam-processed “Di-Huang”, the HPTLC and HPLC chromatographic fingerprint analysis has been carried out. The results showed that in the raw crude drug, the iridoids like catalpol is the major bioactive components, and the oligosaccharides composition kept rather consistent; however, in the steam-processed Di-Huang, iridoids was almost disappeared and the oligosaccharides were hydrolyzed gradually through the repeated steam-heating process. The worst case showed only fructose was detected with other minor residual components in the root tuber. It is due to presumably the uncontrollable steaming process in folk workshops. Defining reasonably the boundary between the “Sheng-Di-Huang” (mild-baking-dried Rehmanniae radix) and “Shu-Di-Huang” (steaming processed Rehmanniae radix) set up by chromatographic fingerprint pattern and standardizing the process would be necessary for assuring the consistent quality of the commercial herbal drugs.
机译：“地黄”（生地黄）是一种特有的中草药，鲜根名为“鲜地黄”（“鲜”是指新鲜的;现在很少有商业可买），轻度干燥的生根“ “ Sheng-Di-Huang”（“ Sheng”是指原料）和蒸汽加工的“ Shu-Di-Huang”（“ Shu”是指蒸汽加工）。根据传统的临床理论，两种草药具有不同的功效和性质。有趣的是，寻找相同药物的治疗功能为何在前处理和后处理之间不同的线索。为了揭示在原料和蒸汽处理的“ Di-Huang”之间发生的虹彩，糖和苯乙醛类化合物的全面变化，已进行了HPTLC和HPLC色谱指纹图谱分析。结果表明，在原料药中，主要成分是梓醇，如catalpol，其低聚糖组成基本保持一致。然而，在经过蒸汽处理的Di-Huang中，通过反复的蒸汽加热过程，鸢尾酮几乎消失了，寡糖逐渐被水解。最坏的情况表明，在块根中仅检测到果糖和其他少量残留成分。大概是由于民间作坊的蒸制过程无法控制。合理定义色谱指纹图谱建立的“ Sheng-Di-Huang”（轻度熟地熟地黄）和“ Shu-Di-Huang”（经蒸煮的熟地黄）之间的界限，并对过程进行标准化，对于确保商业草药的质量一致。

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