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首页> 外文期刊>Bangladesh Journal of Medical Science >Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension
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Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

机译：有高血压家族史的人的醛固酮水平和-344t / C醛固酮合酶

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Background: Genetic factors play an important role in the determination of hypertensive disease in a family. The -344T/C the aldosterone synthase gene has been reported in various populations closely related to hypertension. The aim of this study was to determine the presence of the -344T/C polymorphism of the aldosterone synthase gene and the levels of plasma aldosterone in individuals with and without a family history of hypertension.Methods: This study was a case control design, with healthy individuals with a family history of hypertension as cases (n-42) and those without a family history of hypertension as controls (n=41). The subjects’ plasma aldosterone levels were analysed by enzyme-link immunosorbent assay (ELISA) and the gene polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The data were analysed by an independent sample T-test and Chi square test, and the significance level was set at P<0.05.Result: The frequency of the TT + TC genotype was higher in cases, and this increase was significant different compared to the controls (P<0.046). The frequency of the TT + TC genotype was 2.56 higher in cases than controls. The frequency of the C allele in cases was also significantly different compared to the controls (P = 0.039) and 2.29 more frequent in cases than the controls (P = 0.039). The plasma aldosterone level was 42.35 pg/dL in cases and 34.9 pg/dL in controls (P = 0.616). Plasma aldosterone level in cases with the CC, TC and TT genotypes were 48.29, 40.8 and 35.2 pg/dL, respectively (P = 0.774). Our study concludes that individuals with a family history of hypertension are at a higher risk of developing hypertension. Follow-up studies are required to determine the incidence of hypertension in a person with a family history of hypertension and who is a carrier of genetic risk factors.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.435-440
机译：背景：遗传因素在确定家庭高血压疾病中起着重要作用。已在与高血压密切相关的各种人群中报道了-344T / C醛固酮合酶基因。这项研究的目的是确定是否存在高血压家族史的个体中醛固酮合酶基因的-344T / C多态性和血浆醛固酮的水平。有高血压家族史的健康个体为例（n-42），没有高血压家族史的健康个体为对照组（n = 41）。通过酶联免疫吸附试验（ELISA）分析受试者的血浆醛固酮水平，并通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析基因多态性。通过独立样本T检验和卡方检验分析数据，显着性水平设定为P <0.05。结果：TT + TC基因型的频率在病例中较高，并且这种增加与对照（P <0.046）。 TT + TC基因型的频率比对照组高出2.56。与对照组（P = 0.039）相比，病例中的C等位基因频率也显着不同（P = 0.039），在病例中，C等位基因的频率比对照组高2.29。血浆醛固酮水平为42.35 pg / dL，对照组为34.9 pg / dL（P = 0.616）。 CC，TC和TT基因型患者血浆醛固酮水平分别为48.29、40.8和35.2 pg / dL（P = 0.774）。我们的研究得出结论，有高血压家族史的人患高血压的风险更高。需要进行后续研究以确定具有家族病史且是遗传危险因素携带者的高血压发生率。孟加拉国医学杂志Vol.15（3）2016 p.435-440

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