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首页> 外文期刊>Bangladesh Journal of Medical Science >Antimicrobial sensitivity patterns of salmonella typhi in children
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Antimicrobial sensitivity patterns of salmonella typhi in children

机译：儿童伤寒沙门氏菌的抗菌敏感性模式

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Background: Enteric fever is an important public health problem in developing countries including Bangladesh. A changing antibiotic sensitivity pattern of Salmonella typhi and emergence of resistance has increased to a great concern. Objective: Aim of the study was to investigate the antibiotic sensitivity pattern of Salmonella typhi. Methods: A total of 181 Salmonella typhi samples from 5 to 15 years age group were collected from blood culture during the period of October to December 2014 from IBN SINA Hospital, Dhaka, Bangladesh. Specimens from the blood culture were identified by standard procedures as needed. Antimicrobial susceptibility testing was performed by disk diffusion method according to ‘The Clinical Laboratory Standard Institute’ guidelines. Results: Among the tested antibiotics, S. typhi was susceptible to ceftriaxone 100%, followed by cefixime and gentamicin 99.4%, ciprofloxacin 98.6%, cotrimoxazole 88.9%, azithromycin 88.4 % and least susceptible antibiotic was Ampicillin 62.5% and nalidixic acid 5%. Conclusion: The antimicrobial sensitivity testing showed that the Salmonella typhi were highly sensitive (>88%) to most of the drugs used in this study, whereas nalidixic acid showed only 5% sensitivity. So this study indicates that ceftriaxone, cefixime, gentamicin and ciprofloxacin can be used as a first line therapy and nalidixic acid should be avoided for treatment.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.416-418
机译：背景：肠热是包括孟加拉国在内的发展中国家的重要公共卫生问题。伤寒沙门氏菌的抗生素敏感性模式的变化和耐药性的出现已引起极大关注。目的：研究伤寒沙门氏菌的敏感性模式。方法：2014年10月至2014年12月期间，从孟加拉国达卡的IBN SINA医院的血液培养中收集了181份5至15岁年龄组的伤寒沙门氏菌样本。根据需要通过标准程序鉴定血培养标本。根据“临床实验室标准协会”的指南，采用圆盘扩散法进行了药敏试验。结果：在测试的抗生素中，伤寒沙门氏菌对头孢曲松的敏感度为100％，其次是头孢克肟和庆大霉素99.4％，环丙沙星98.6％，cotrimoxazole 88.9％，阿奇霉素88.4％，最不敏感的抗生素是氨苄青霉素62.5％和萘啶酸5％。结论：抗菌敏感性测试表明，伤寒沙门氏菌对本研究中使用的大多数药物高度敏感（> 88％），而萘啶酸仅显示5％的敏感性。因此，本研究表明头孢曲松，头孢克肟，庆大霉素和环丙沙星可以作为一线治疗药物，应避免使用萘啶酸。孟加拉国医学杂志Vol.15（3）2016 p.416-418

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