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首页> 外文期刊>Bangladesh Journal of Medical Science >Evaluation subchronic toxic effect of polysaccharide peptide on lipid and hematologic profile in Rattus norvegicus strain Wistar
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Evaluation subchronic toxic effect of polysaccharide peptide on lipid and hematologic profile in Rattus norvegicus strain Wistar

机译：评估多糖肽对褐家鼠Wistar脂质和血液学特征的亚慢性毒性作用

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Objective: There are many unknown safety for consumption in a compound of medicinal plants, one of them is polysaccharide peptide (PSP) of the extract of Ganoderma lucidum. Polysaccharide peptide (PSP) from Ganoderma lucidum mushroom extract is a bioactive substances found in the mushroom that is expected to be a drug that is safe for consumption. It is an antioxidant that has been used in the wider community as a chronic hepatopathic medicine, hypertension, and hyperglycemia. PSP cannot be circulated to the public before passing some toxicity tests to obtain information about its safety and to investigate the effect. There are many things that can be assessed from this toxicity test, some of them are lipid profile that includes (cholesterol, HDL, LDL, and TG) and blood profile (leukocytes, erythrocytes, and platelets).Materials and Methods: This study used experimental post test only control group design. The sample consisted of 80 Rattus norvegicus?Wistar strain (40 males and 40 females) were divided into normal group, the group with the administration of a dose PSP 300, 600, 1200 mg/kg/hr) for 90 days. Parameters measured were lipid and hematological profile.Results and Discussion: The result of the analysis using ANOVA showed no significant effect on the administration of PSP on the level lipid and hematologic profile. The examination showed not significant at the lipid profile (cholesterol, TG, HDL, and LDL) and leukocytes. It is same as platelet and erythrocytes profile whereas there is only PCT, MCV, MCH, RBC, and RDW changed significantly, but still within normal limits.Conclusion: Administration Polysaccharide peptide in subchronic study mostly showed no significant effect on the levels of lipid profiles and hematology even though there is significant effect in some parameters but it still within the normal limit. Findings from this study suggest that Polysaccharide peptide of Ganoderma lucidum is safe and can be exploited in healthcare delivery systems.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.409-415
机译：目的：食用多种药用植物存在许多未知的安全性，其中之一是灵芝提取物的多糖肽（PSP）。灵芝蘑菇提取物中的多糖肽（PSP）是蘑菇中发现的一种生物活性物质，有望成为一种安全食用的药物。它是一种抗氧化剂，已在更广泛的社区中用作慢性肝病药物，高血压和高血糖症。 PSP在通过某些毒性测试以获取其安全性信息并调查其效果之前，不能向公众分发。可以通过该毒性测试评估很多东西，其中一些是脂质谱，包括（胆固醇，HDL，LDL和TG）和血液谱（白细胞，红细胞和血小板）。材料和方法：实验后测仅用于对照组设计。将由80只褐家鼠？Wistar菌株（40例男性和40例女性）组成的样品分为正常组，该组给予PSP 300、600、1200 mg / kg / hr的剂量，持续90天。结果和讨论：使用ANOVA进行分析的结果表明，PSP的给药对血脂和血液学水平没有显着影响。该检查显示血脂（胆固醇，TG，HDL和LDL）和白细胞的分布不明显。它与血小板和红细胞谱图相同，而只有PCT，MCV，MCH，RBC和RDW发生了显着变化，但仍在正常范围内。结论：给药亚慢性研究中的多糖肽对脂质谱图水平几乎没有明显影响和血液学，即使某些参数有显着影响，但仍在正常范围内。这项研究的结果表明，灵芝多糖肽是安全的，可以在医疗保健提供系统中使用。孟加拉国医学杂志Vol.15（3）2016 p.409-415

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