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Susceptibility of Bifidobacteria of Animal Origin to SelectedAntimicrobial Agents

机译：动物来源的双歧杆菌对某些抗菌剂的敏感性

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Strains of the genusBifidobacteriumare frequently used as probiotics, for which the absence of acquired antimicrobial resistance has become an important safety criterion. This clarifies the need for antibiotic susceptibility data for bifidobacteria. Based on a recently published standard for antimicrobial susceptibility testing of bifidobacteria with broth microdilution method, the range of susceptibility to selected antibiotics in 117 animal bifidobacterial strains was examined. Narrow unimodal MIC distributions either situated at the low-end (chloramphenicol, linezolid, and quinupristin/dalfopristin) or high-end (kanamycin, neomycin) concentration range could be detected. In contrast, the MIC distribution of trimethoprim was multimodal. Data derived from this study can be used as a basis for reviewing or verifying present microbiological breakpoints suggested by regulatory agencies to assess the safety of these micro-organisms intended for the use in probiotics.
机译：双歧杆菌属的菌株通常用作益生菌，对于它们来说，缺乏获得的抗药性已成为重要的安全标准。这明确了双歧杆菌对抗生素敏感性数据的需求。基于最近发布的肉汤微稀释法对双歧杆菌进行药敏试验的标准，检查了117种动物双歧杆菌菌株对所选抗生素的敏感性范围。可以检测到位于低端（氯霉素，利奈唑胺和奎奴普丁/达福普汀）或高端（卡那霉素，新霉素）浓度范围的窄单峰MIC分布。相反，甲氧苄啶的MIC分布是多峰的。这项研究得出的数据可以用作审查或验证监管机构建议的当前微生物学断点的基础，以评估这些微生物用于益生菌的安全性。

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