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Antiepidermal Growth Factor Receptor Monoclonal Antibodies: Applications in Colorectal Cancer

机译:抗表皮生长因子受体单克隆抗体:在结直肠癌中的应用

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Patients with metastatic colorectal cancer have a poor prognosis and present a challenge to clinicians. The role of the antiepidermal growth factor receptor (EGFR) pathway in tumorogenesis and tumor progression has been well defined. This paper will review the use of anti-EGFR monoclonal antibodies in the treatment of operable, as well as metastatic colorectal cancer both in the setting of KRAS mutation unselected patients and later in KRAS wild-type patients. Active investigations designed to further identify predictive biomarkers that may be potentially druggable are reviewed as well.
机译:转移性结直肠癌患者预后较差,对临床医生提出了挑战。抗表皮生长因子受体(EGFR)途径在肿瘤发生和肿瘤进展中的作用已得到明确定义。本文将综述在未选择的KRAS突变患者以及后来在KRAS野生型患者中使用抗EGFR单克隆抗体治疗可手术的以及转移性结直肠癌的方法。还对旨在进一步确定可能具有药物作用的预测性生物标志物的主动研究进行了审查。

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