The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck

Jeffery S.Russell; A. DimitriosColevas

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The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck

机译：表皮生长因子受体单克隆抗体在头颈部鳞状细胞癌中的应用

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Targeting of the EGF receptor (EGFR) has become a standard of care in several tumor types. In squamous cell carcinoma of the head and neck, monoclonal antibodies directed against EGFR have become a regular component of therapy for curative as well as palliative treatment strategies. These agents have anti-tumor efficacy as a single modality and have demonstrated synergistic tumor killing when combined with radiation and/or chemotherapy. While cetuximab has been the primary anti-EGFR monoclonal antibody used in the US, variant anti-EGFR monoclonal antibodies have been used in several clinical studies and shown benefit with improved toxicity profiles. Next generation anti-EGFR monoclonal antibodies may demonstrate multi-target epitope recognition, enhanced immune cell stimulation, or conjugation with radioisotopes in order to improve clinical outcomes. Identification of the specific patient subset that would optimally benefit from anti-EGFR monoclonal antibodies remains an elusive goal.

机译：EGF受体（EGFR）的靶向已成为几种肿瘤类型的护理标准。在头颈部鳞状细胞癌中，针对EGFR的单克隆抗体已成为根治性和姑息性治疗策略的常规组成部分。这些药物具有单一形式的抗肿瘤功效，并且在与放疗和/或化学疗法联合使用时，已显示出协同的杀伤肿瘤作用。尽管西妥昔单抗一直是美国使用的主要抗EGFR单克隆抗体，但变异的抗EGFR单克隆抗体已用于多项临床研究中，并显示出改善的毒性特征的益处。下一代抗EGFR单克隆抗体可能会表现出多目标表位识别，增强的免疫细胞刺激或与放射性同位素结合的作用，以改善临床疗效。鉴定最能受益于抗EGFR单克隆抗体的特定患者亚组仍然是一个遥不可及的目标。

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《Chemotherapy Research and Practice》 |2012年第1期|共13页
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Jeffery S.Russell; A. DimitriosColevas;
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中图分类临床医学;
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1. In vivo and in situ imaging of head and neck squamous cell carcinoma using near-infrared fluorescent quantum dot probes conjugated with epidermal growth factor receptor monoclonal antibodies in mice [J] . YangK., ZhaoC., CaoY.-A., Oncology reports . 2012,第6期

机译：使用与表皮生长因子受体单克隆抗体结合的近红外荧光量子点探针对小鼠头颈部鳞状细胞癌进行体内和原位成像
2. In vitro study of normoxic epidermal growth factor receptor-induced hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti-epidermal growth factor receptor therapy [J] . Secades Pablo, de Santa-Maria Ines Saenz, Merlo Anna, Head and neck: Journal for the sciences and specialities of the head and neck . 2015,第8期

机译：常氧表皮生长因子受体诱导的缺氧诱导因子-1-α，血管内皮生长因子和BNIP3在头颈部鳞状细胞癌细胞系中的体外研究：对抗表皮生长因子受体治疗的意义
3. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines [J] . Molecular pharmacology. . 2013,第4期

机译：由成纤维细胞生长因子受体，表皮生长因子受体，v-erb-b2红细胞白血病病毒病毒癌基因同源物2和肝细胞生长因子受体组成的受体酪氨酸激酶网络驱动头颈部鳞状细胞癌细胞系的生长和存活
4. The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 (Iressa) Suppresses Proliferation and Invasion of Human Oral Squamous Carcinoma Cells via p53 Independent and MMP, uPAR Dependent Mechanism [C] . EUN JU LEE, JIN HA WHANG, NAM KYEONG JEON, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：表皮生长因子受体酪氨酸激酶抑制剂ZD1839（Iressa）通过独立于p53和MMP，uPAR依赖性机制抑制人口腔鳞状细胞癌细胞的增殖和侵袭
5. The prognostic potential of the epidermal growth factor receptor and nuclear factor kappa B pathways and associated therapeutic strategies in patients with squamous cell carcinoma of the head and neck. [D] . Wirth, Pamela Susan. 2010

机译：表皮生长因子受体和核因子κB通路对头颈部鳞状细胞癌患者的预后潜力及相关治疗策略。
6. The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck [O] . Jeffery S. Russell, A. Dimitrios Colevas 2012

机译：表皮生长因子受体单克隆抗体在头颈部鳞状细胞癌中的应用
7. Immunological Effect of Anti-Epidermal Growth Factor Receptor (EGFR) Antibodies in Squamous Cell Carcinoma of the Head and Neck (HNSCC): the Present and the Future [O] . Denaro Nerina, Elvio Grazioso Russi, Lo Nigro Cristiana, 2016

机译：抗表皮生长因子受体（EGFR）抗体在头部鳞状细胞癌中的免疫效应（HNSCC）：目前与未来

The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck

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