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首页> 外文期刊>Chemotherapy Research and Practice >Induction Chemotherapy in Locally Advanced Pharyngolaryngeal Cancers with Stridor: Is It Feasible and Safe?
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Induction Chemotherapy in Locally Advanced Pharyngolaryngeal Cancers with Stridor: Is It Feasible and Safe?

机译：伴咽癌的局部晚期咽喉癌的诱导化学疗法：既可行又安全吗？

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Background. The standard initial management of patients with locally advanced pharyngolaryngeal presenting with stridor is tracheostomy. Tracheostomy has been shown to negatively impact cancer-related outcomes.Methods. Retrospective analysis of prospectively collected data of 9 patients, who underwent induction chemotherapy with the aim of prevention of tracheostomy. Presenting features, time to resolution of stridor, and further management are reported.Results. Eight out of 9 patient received chemotherapy within 12 hours of presentation with stridor. There were 4 patients each with primary hypopharynx and larynx. The stage was IVA in 6 patients and IVB in 2 patients. In all patients receiving immediate chemotherapy, clinical stridor resolved within 48 hours. The radiological response rate was 62.5%. The median reduction in size of tumor was 37%.Conclusion. Immediate neoadjuvant chemotherapy is a feasible and safe option for patients presenting with early stridor and helps in resolution of stridor and avoiding tracheostomy.
机译：背景。伴有喘鸣的局部晚期咽喉炎患者的标准初始治疗是气管切开术。气管切开术已被证明会对与癌症相关的结果产生负面影响。回顾性分析9例接受预防性气管切开术的诱导化疗患者的资料。报告了特征，喘鸣的解决时间和进一步的管理。 9名患者中有8名在出现喘鸣后12小时内接受了化疗。分别有4例原发性下咽和喉。分期为6例患者的IVA和2例患者的IVB。在所有接受立即化疗的患者中，临床喘鸣在48小时内消失。放射反应率为62.5％。肿瘤大小的中位数减少为37％。对于出现早期str大喘鸣的患者，立即进行新辅助化疗是一种可行且安全的选择，有助于解决str大喘鸣和避免气管切开术。

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