Preparation andIn VivoEvaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

Hardeep S.Oberoi; Natalia V.Nukolova; YiZhao; Samuel M.Cohen; Alexander V.Kabanov; Tatiana K.Bronich

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Preparation andIn VivoEvaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

机译：负载二氯（1,2-二氨基环己烷）铂（II）的核交联聚合物胶束的制备和体内评价

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The therapeutic performance of oxaliplatin can be improved by incorporating the centralcis-dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into the core cross-linked block copolymer micelles. We describe here the preparation, cellular uptake, andin vivoevaluation of core cross-linked micelles loaded with DACHPt. Stable drug-loaded micelles were prepared at high drug loading (~25 w/w%) and displayed a considerably increasedin vitrocytotoxicity compared to free oxaliplatin against A2780 ovarian cancer cells. The DACHPt-loaded micelle formulation was well tolerated in mice and exhibited improved antitumor activity than oxaliplatin alone in an ovarian tumor xenograft model.

机译：通过将中心顺式-二氯（1,2-二氨基环己烷）铂（II）（DACHPt）基序并入核心交联的嵌段共聚物胶束中，可以提高奥沙利铂的治疗性能。我们在这里描述了载有DACHPt的核心交联胶束的制备，细胞摄取和体内评估。在高载药量（〜25％w / w％）下制备了稳定的载药胶束，与游离奥沙利铂相比，抗A2780卵巢癌细胞的体外细胞毒性显着提高。载有DACHPt的胶束制剂在小鼠中具有良好的耐受性，并且在卵巢肿瘤异种移植模型中比单独使用奥沙利铂具有更好的抗肿瘤活性。

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《Chemotherapy Research and Practice》 |2012年第1期|共10页
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Hardeep S.Oberoi; Natalia V.Nukolova; YiZhao; Samuel M.Cohen; Alexander V.Kabanov; Tatiana K.Bronich;
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中图分类临床医学;
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1. Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles [J] . Cabral H, Nishiyama N, Okazaki S, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2005,第1a3期

机译：载有二氯（1,2-二氨基环己烷）铂（II）（DACHPt）的聚合物胶束的制备和生物学性质
2. Polymeric micelles loaded with (1,2-diaminocyclohexane)platinum(II) against colorectal cancer [J] . Takako Nirei, Soichiro Ishihara, Toshiaki Tanaka, Journal of Surgical Research: Clinical and Laboratory Investigation . 2017,第期

机译：加载（1,2-二氨基环己烷）铂（II）的聚合物胶束抵抗结直肠癌
3. Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis [J] . Rafi M., Cabral H., Kano M.R., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2012,第2期

机译：掺入（1,2-二氨基环己烷）铂（II）的聚合物胶束可抑制原位肝硬化性胃肿瘤的生长及其淋巴结转移
4. Dichloro(1,2-diaminocyclohexane) Platinum(II) (DACHPt) Loaded Polymer Micelles with Cross-Linked Core: Preparation and Characterization [C] . Hardeep S. Oberoi, Nataliya V. Nukolova, Tatiana K. Bronich PMSE Symposia . 2011

机译：二氯（1,2-二氨基环己烷）铂（II）（分别）具有交联核心的加载聚合物胶束：制备和表征
5. Polymer micelles with cross-linked ionic cores for delivery of platinum anticancer agents. [D] . Oberoi, Hardeep Singh. 2011

机译：具有交联离子核的聚合物胶束，用于递送铂类抗癌剂。
6. Preparation and In Vivo Evaluation of Dichloro(12-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles [O] . Hardeep S. Oberoi, Natalia V. Nukolova, Yi Zhao, 2012

机译：载有二氯（12-二氨基环己烷）铂（II）的核交联聚合物胶束的制备和体内评价
7. Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles [O] . Hardeep S. Oberoi, Natalia V. Nukolova, Yi Zhao, 2012

机译：二氯（1,2-二氨基环己烷）铂（II） - 加载芯交联聚合物胶束的制备及体内评价
8. 1,2-Diaminocyclohexane Platinum (II) Complexes having Antineoplastic Activity [R] . Gale, G. R. , Meischen, S. J. 1979

机译：1,2-二氨基环己烷铂（II）具有抗肿瘤活性的复合物

Preparation andIn VivoEvaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

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