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Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei

机译:布氏锥虫的基础身体结构和细胞周期依赖性生物发生

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Basal bodies are microtubule-based organelles that assemble cilia and flagella, which are critical for motility and sensory functions in all major eukaryotic lineages. The core structure of the basal body is highly conserved, but there is variability in biogenesis and additional functions that are organism and cell type specific. Work carried out in the protozoan parasite Trypanosoma brucei has arguably produced one of the most detailed dissections of basal body structure and biogenesis within the context of the flagellar pocket and associated organelles. In this review, we provide a detailed overview of the basic basal body structure in T. brucei along with the accessory structures and show how basal body movements during the basal body duplication cycle orchestrate cell and organelle morphogenesis. With this in-depth three-dimensional knowledge, identification of many basal body genes coupled with excellent genetic tools makes it an attractive model organism to study basal body biogenesis and maintenance.
机译:基体是基于微管的细胞器,可组装纤毛和鞭毛,这对于所有主要的真核生物系的运动性和感觉功能都至关重要。基体的核心结构高度保守,但生物发生和生物功能和细胞类型特异性的其他功能存在差异。在原生动物寄生虫布鲁氏锥虫中进行的工作可以说是在鞭毛袋和相关细胞器的背景下产生了最详细的基础身体结构和生物发生解剖之一。在这篇综述中,我们提供了布鲁氏锥虫的基本基础身体结构及其附属结构的详细概述,并展示了在基础身体复制周期中基础身体的运动如何协调细胞和细胞器的形态发生。凭借这种深入的三维知识,许多基础体基因的鉴定以及出色的遗传工具使其成为研究基础体生物发生和维持的有吸引力的模型生物。

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