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Naegleria : a classic model for de novo basal body assembly

机译:内格勒尼亚(Naegleria):从头开始进行基体组装的经典模型

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The amoeboflagellate Naegleria was one of the first organisms in which de novo basal body/centriole assembly was documented. When in its flagellate form, this single-celled protist has two flagella that are templated by two basal bodies. Each of these basal bodies is structurally well conserved, with triplet microtubules and well-defined proximal cartwheel structures, similar to most other eukaryotic centrioles. The basal bodies are anchored to the nucleus by a single, long striated rootlet. The Naegleria genome encodes many conserved basal body genes whose expression is induced prior to basal body assembly. Because of the rapid and synchronous differentiation from centriole-less amoebae to temporary flagellates with basal bodies, Naegleria offers one of the most promising systems to study de novo basal body assembly, as well as the mechanisms regulating the number of centrioles assembled per cell.
机译:变形虫鞭毛虫是记录有从头基体/中心体装配的最早的生物之一。当呈鞭毛状时,该单细胞原生生物具有两个鞭毛,两个鞭毛由两个基体作为模板。这些基体中的每一个在结构上都保存完好,具有三重态微管和轮廓分明的近端车轮结构,与大多数其他真核中心体相似。基体通过单个长条状小根固定在细胞核上。 Naegleria基因组编码许多保守的基体基因,其表达在基​​体组装之前被诱导。由于从无中心粒状变形虫到带有基体的临时鞭毛迅速而同步的分化,Naegleria提供了最有前途的系统来研究从头开始的基体装配,以及调节每个细胞装配的中心粒数量的机制。

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