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The rise and fall of basal bodies in the nematode Caenorhabditis elegans

机译:线虫秀丽隐杆线虫基体的兴衰

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The free-living nematode, Caenorhabditis elegans , is a widely used genetic model organism for investigations into centriole and cilia biology. Only sensory neurons are ciliated in C. elegans ; morphologically diverse cilia in these neurons are nucleated by basal bodies located at the dendritic endings. C. elegans centrioles comprise a central tube with a symmetric array of nine singlet microtubules. These singlet microtubules remodel in a subset of sensory neurons to form the doublet microtubules of the basal bodies. Following initiation of ciliogenesis, the central tube, but not the outer centriole wall, of the basal body degenerates. Recent ultrastructural characterization of basal body architecture and remodeling have laid the foundation for future studies into mechanisms underlying different aspects of basal body genesis, remodeling, and intracellular positioning.
机译:自由生存的线虫秀丽隐杆线虫是广泛用于研究中心粒和纤毛生物学的遗传模型生物。线虫中仅有感觉神经元纤毛;这些神经元中形态多样的纤毛被位于树突末端的基核所成核。秀丽隐杆线虫包括具有九个单线态微管的对称阵列的中心管。这些单线态微管在感觉神经元的子集中重塑以形成基体的双线态微管。在开始纤毛发生后,基体的中央管而不是中心质外壁退化。最近对基础身体结构和重塑的超微结构表征为基础研究基础身体起源,重塑和细胞内定位的不同方面奠定了基础。

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