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首页> 外文期刊>Ciencia Rural >Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
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Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints

机译：口服糖胺和硫酸软骨素对骨关节炎马关节滑液生物标志物的影响

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Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix.
机译：几项主要在体外的研究表明，硫酸软骨素（CS）和葡萄糖胺（GlcN）确实具有软骨保护和抗炎作用。本研究的目的是调查口服CS / GlcN补充剂是否对马骨关节炎关节滑液中的CS，透明质酸（HA）和前列腺素E2（PGE2）浓度有影响。胫骨joint关节中患有轻度骨关节炎（OA）的马，每天接受CS和GlcN（2.8 / 3.1 g）的PO剂量，持续25天。在治疗前（第0天）和每7天收集滑液（SF）和尿液样本，直到第55天（治疗结束后30天）。口服治疗后尿CS升高，表明该化合物全身分布。关于SF，在治疗结束后CS浓度增加，然后恢复到基线，而HA和PGE2浓度未改变。尽管有全身性分布，但口服CS / GlcN 25天仍不足以作为抗炎支持。但是，可以推断出对软骨基质有合成代谢作用。

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