Alternatives for identifying drug interactions among adverse drug reactions in hospital units

Diego Zapelini?Nascimento; Gabriela Moreno?Marques; Fabiana?Schuelter-Trevisol

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Alternatives for identifying drug interactions among adverse drug reactions in hospital units

机译：在医院单位中识别药物不良反应之间药物相互作用的替代方法

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O estudo de Nagai et al.1 representa uma excelente alternativa para identificar as rea??es adversas a medicamentos (RAM). Esta é uma discuss?o relevante, considerando as políticas de uso racional de medicamentos promovidas por várias agências reguladoras ao redor do mundo, como a Food and Drug Administration. Nesse sentido, consideramos importante salientar que entre as RAM, as intera??es medicamentosas (IM) s?o as mais frequentes, sendo que mais de 30% das RAM s?o causadas por IM, resultando em morbidade significativa a cada ano2. Além dos rastreadores apresentados por Nagai et al.1, os profissionais da área da saúde precisam reconhecer o perfil clínico dos pacientes, as IM potenciais existentes, bem como manejar, de forma adequada, as possíveis RAM que podem ser desencadeadas pelo uso de diversos medicamentos3.

机译：Nagai等人1的研究代表了一种识别药物不良反应（ADR）的极好的选择。这是一个相关的讨论，考虑到世界各地各种监管机构（例如食品和药物管理局）推行的合理用药政策。从这个意义上讲，我们认为必须指出，在ADR中，药物相互作用（IM）是最常见的，超过30％的ADR是由MI引起的，每年导致很高的发病率2。除了Nagai等人[1]提出的追踪器外，卫生专业人员还需要认识到患者的临床情况，现有的潜在MI，并适当管理可能因使用各种药物而引发的ADRs3。。

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《Ciência & Saúde Coletiva》 |2019年第4期|共2页
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Diego Zapelini?Nascimento; Gabriela Moreno?Marques; Fabiana?Schuelter-Trevisol;
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中图分类临床医学;
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1. Serious adverse drug reactions identified as Drug-Drug interactions by the French spontaneous reporting system [J] . Fundamental & clinical pharmacology. . 2019,第S1期

机译：根据法国自发性报告系统确定了严重的不良药物反应作为药物 - 药物相互作用
2. Identifying adverse drug reactions associated with drug-drug interactions: data mining of a spontaneous reporting database in Italy. [J] . Leone R, Magro L, Moretti U, Drug safety: An international journal of medical toxicology and drug experience . 2010,第8期

机译：识别与药物相互作用有关的药物不良反应：意大利自发报告数据库的数据挖掘。
3. Surveillance of adverse drug reactions and drug-drug interactions with pediatric oncology patients in a south Indian tertiary care hospital [J] . Joseph Bency, Scott Julius X., Ganesan Rajanandh M. Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners . 2020,第5期

机译：在南印度第三节护理医院中对儿科肿瘤患者进行不良药物反应和药物 - 药物相互作用的监测
4. Discovering Drug-Drug Interactions and Associated Adverse Drug Reactions with Triad Prediction in Heterogeneous Healthcare Networks [C] . Haodong Yang, Christopher C. Yang IEEE International Conference on Healthcare Informatics . 2016

机译：在异类医疗网络中发现药物相互作用以及与三联征预测相关的不良药物反应
5. Involvement of Th17 Pathway in Adverse Drug Reactions: Mechanistic Investigation of Drug-Induced Autoimmunity and Drug-induced Liver Injury. [D] . Zhu, Ervin Xu. 2012

机译：Th17途径参与药物不良反应：药物诱发的自身免疫和药物诱发的肝损伤的机制研究。
6. Identifying and Characterizing Serious Adverse Drug Reactions Associated With Drug-Drug Interactions in a Spontaneous Reporting Database [O] . Lara Magro, Elena Arzenton, Roberto Leone, 2020

机译：鉴定和表征自发报告数据库中与药物 - 药物相互作用相关的严重不良药物
7. Identifying and Characterizing Serious Adverse Drug Reactions Associated With Drug-Drug Interactions in a Spontaneous Reporting Database [O] . Lara Magro, Elena Arzenton, Roberto Leone, 2021

机译：鉴定和表征自发报告数据库中与药物 - 药物相互作用相关的严重不良药物
8. Data-driven prediction of adverse drug reactions induced by drug drug interactions. [R] . Liu, R., AbdulHameed, M. D. M., Kumar, K., 2017

机译：由药物相互作用诱导的药物不良反应的数据驱动预测。

Alternatives for identifying drug interactions among adverse drug reactions in hospital units

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