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首页> 外文期刊>Circulation journal >Effect of Left Ventricular Dyssynchrony on Cardiac Sympathetic Activity in Heart Failure Patients With Wide QRS Duration
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Effect of Left Ventricular Dyssynchrony on Cardiac Sympathetic Activity in Heart Failure Patients With Wide QRS Duration

机译：QRS持续时间宽的心力衰竭患者左心室不同步对心脏交感神经活动的影响

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Background: Dyssynchrony has various detrimental effects on cardiac function, but its effect on cardiac sympathetic activity is not fully understood. Methods and Results: We studied 50 heart failure patients who underwent cardiac resynchronization therapy (CRT). Cardiac sympathetic activity was assessed by 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy as the delayed heart-to-mediastinum ratio (H/M ratio). Echocardiography was performed before and 7 months after CRT, and response was defined as a ≥15% decrease in end-systolic volume. Dyssynchrony was determined by the time difference between the anteroseptal-to-posterior wall using speckle-tracking radial strain (≥130ms predefined as significant). H/M ratio in patients with dyssynchrony was less than that in patients without dyssynchrony (1.62±0.31 vs. 1.82±0.36, P123I-MIBG scintigraphy may be valuable for predicting the response to CRT. ( Circ J 2012; 76: 382-389)
机译：背景：不同步对心脏功能有多种有害作用，但对心脏交感神经活动的影响尚不完全清楚。方法和结果：我们研究了50例接受心脏再同步治疗（CRT）的心力衰竭患者。通过 123 I-蛋氨酸苄基胍（ 123 I-MIBG）闪烁显像评估心脏交感神经活动，以延迟的心脏与纵隔之比（H / M比）为标准。在CRT之前和之后7个月进行超声心动图检查，反应定义为收缩末期容积减少≥15％。通过斑点跟踪径向应变（≥130ms定义为显着性），通过前间隔与后壁之间的时间差来确定不同步。具有不同步性的患者的H / M比小于没有不同步性的患者（H / M比（1.62±0.31 vs. 1.82±0.36，P123 I-MIBG闪烁显像）可能对预测对CRT的反应有价值（Circ J 2012; 76：382-389）

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