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首页> 外文期刊>Circulation journal >Hair Magnesium, But Not Serum Magnesium, Is Associated With Left Ventricular Wall Thickness in Hemodialysis Patients
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Hair Magnesium, But Not Serum Magnesium, Is Associated With Left Ventricular Wall Thickness in Hemodialysis Patients

机译：血液透析患者的头发镁而不是血清镁与左心室壁厚度有关

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Background: ?Extracellular magnesium (Mg) accounts for approximately 1% of the total body Mg. Clinically, serum Mg concentration is measured, but it does not necessarily reflect total body Mg status. Although relationships have been reported between reduced Mg and cardiovascular disease in non-dialysis patients, there have been few such studies in hemodialysis patients. It was hypothesized that reduced Mg, as represented by lower Mg concentration in the hair, would be associated with echocardiographic parameters in chronic hemodialysis patients. Methods and Results: ?Hair Mg concentration was measured in 79 male hemodialysis patients using inductively coupled plasma mass spectrometry, and the relationships between hair Mg concentration and echocardiographic parameters were investigated. There was no significant correlation between Mg concentration in the hair and in serum. Hair Mg concentration in the patients with high-left ventricular mass index (LVMI) was significantly lower than that in the low-LVMI patients. Hair Mg concentration correlated significantly and negatively with posterior left ventricular wall thickness, interventricular septum thickness, left ventricular wall thickness (LVWT), and relative wall thickness. Serum Mg concentration, however, did not correlate with any of these echocardiographic parameters. Conclusions: ?In hemodialysis patients, hair Mg concentration is a biomarker, independent of serum Mg concentration. Hair Mg, but not serum Mg, was significantly and negatively associated with LVWT. Reduced tissue Mg concentration, as measured in the hair, may be associated with left ventricular hypertrophy in hemodialysis patients.??( Circ J ?2013; 77: 3029–3036)
机译：背景：？细胞外镁（Mg）约占人体总镁的1％。在临床上，可以测量血清镁的浓度，但不一定反映出全身的镁状态。尽管已经报道了非透析患者中​​Mg降低与心血管疾病之间的关系，但在血液透析患者中​​很少有此类研究。据推测，以头发中较低的Mg浓度表示的Mg降低与慢性血液透析患者的超声心动图参数有关。方法与结果：采用电感耦合等离子体质谱法测定了79例男性血液透析患者的头发Mg浓度，并研究了头发Mg浓度与超声心动图参数之间的关系。头发和血清中的镁含量之间没有显着相关性。高左心室质量指数（LVMI）患者的头发Mg浓度显着低于低LVMI患者。头发中的Mg浓度与左后室壁厚，室间隔，左室壁厚（LVWT）和相对壁厚呈显着负相关。然而，血清镁浓度与这些超声心动图参数均不相关。结论：？在血液透析患者中​​，头发Mg浓度是一种生物标志物，与血清Mg浓度无关。头发中的镁而不是血清中的镁与LVWT呈显着负相关。血液透析患者头发中的组织中Mg浓度降低，可能与左心室肥大有关。（Circ J？2013; 77：3029–3036）

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