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首页> 外文期刊>Circulation journal >Decreased Endothelial Progenitor Cells and Increased Serum Glycated Albumin Are Independently Correlated With Plaque-Forming Carotid Artery Atherosclerosis in Type 2 Diabetes Patients Without Documented Ischemic Disease
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Decreased Endothelial Progenitor Cells and Increased Serum Glycated Albumin Are Independently Correlated With Plaque-Forming Carotid Artery Atherosclerosis in Type 2 Diabetes Patients Without Documented Ischemic Disease

机译：内皮祖细胞减少和血清糖化白蛋白增加与2型糖尿病无记录性缺血性疾病的斑块形成颈动脉粥样硬化独立相关

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Background: The aim of the present study was to investigate the serum levels of endothelial progenitor cells (EPCs) in type 2 diabetic patients without documented ischemic disease and the association between EPCs and atherosclerotic plaque formation in the carotid artery. Methods and Results: A clinic-based, prospective study of type 2 diabetic patients was conducted. A total of 73 subjects were enrolled in this study after cardiac magnetic resonance imaging and ankle-brachial index measurements to exclude patients with ischemic disease. Plaque formation in the carotid artery was measured on ultrasonography. Circulating EPCs (CD34+/CD133+/CD309+ cells) were counted on flow cytometry. Compared to subjects without carotid artery plaques, patients with plaques were significantly older (P=0.006) and had decreased EPC count (P=0.027). Serum glycated albumin (GA) level and the GA/glycated hemoglobin ratio tended to decrease in patients with plaques (P=0.091 and 0.067, respectively). Other cardiovascular disease risk factors were not significantly different between the 2 groups. On binary logistic regression analysis old age, low EPC count, and high serum GA level were independently correlated with carotid artery plaque formation. Conclusions: EPC count and serum GA level appear to be a protective and an aggravating factor for endothelial damage, respectively, and therefore, a reduced EPC count or an increased GA level results in atherosclerotic plaque formation in type 2 diabetic patients. ( Circ J 2012; 76: 2273–2279)
机译：背景：本研究的目的是调查无记录的缺血性疾病的2型糖尿病患者的血清内皮祖细胞（EPC）的水平，以及EPC与颈动脉粥样硬化斑块形成之间的关系。方法和结果：对2型糖尿病患者进行了基于临床的前瞻性研究。在心脏磁共振成像和踝肱指数测量后，共有73名受试者参加了本研究，以排除缺血性疾病患者。超声检查颈动脉斑块的形成。在流式细胞仪上计数循环中的EPC（CD34 + / CD133 + / CD309 + 细胞）。与没有颈动脉斑块的受试者相比，有斑块的患者年龄更大（P = 0.006），并且EPC计数降低（P = 0.027）。斑块患者的血清糖基化白蛋白（GA）水平和GA /糖化血红蛋白比率趋于降低（分别为P = 0.091和0.067）。两组之间的其他心血管疾病危险因素无显着差异。在二元逻辑回归分析中，年龄，低EPC计数和高血清GA水平与颈动脉斑块形成独立相关。结论：EPC计数和血清GA水平似乎分别是内皮损伤的保护性因素和加重因素，因此，降低EPC计数或增加GA水平会导致2型糖尿病患者的动脉粥样硬化斑块形成。 （Circ J 2012; 76：2273-2279）

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