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首页> 外文期刊>Circulation journal >Left Ventricular Global Strain for Estimating Relaxation and Filling Pressure　– A Multicenter Study –
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Left Ventricular Global Strain for Estimating Relaxation and Filling Pressure　– A Multicenter Study –

机译：估计舒张和充盈压力的左心室整体应变–多中心研究–

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Background: Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter – strain or strain rate – and which direction of myocardial deformation – longitudinal or circumferential – is the most useful marker of LV relaxation and filling pressure. Methods?and?Results: We conducted a prospective multicenter study and compared the correlation of tissue Doppler- and STE-derived parameters with the time constant of LV pressure decay (τ) and LV mean diastolic pressure (MDP) in 77 patients. The correlation of early-diastolic mitral annular velocity (e′) with τ was weak (r=?0.32, P<0.01), and that of peak longitudinal strain (LS) was the strongest (r=?0.45, P<0.001) among the STE-derived parameters. There was a modest correlation between LVMDP and the ratio of early-diastolic inflow velocity (E) to e′ (E/e′) (r=0.50, P<0.001). In contrast, the ratio of E to LS (E/LS) correlated strongly with LVMDP (r=0.70, P<0.001). The correlation of E/LS with LVMDP was significantly better than that for E/e′ (P<0.01). Receiver-operating characteristic analysis showed that E/LS had the largest area under the curve for distinguishing elevated LVMDP (E/LS 0.86, E/e′ 0.74, E/A 0.67). Conclusions: STE-derived longitudinal parameters correlated well with LV relaxation and filling pressure. In particular, E/LS could be more accurate than E/e′ for estimating LV filling pressure. ( Circ J 2016; 80: 1163–1170)
机译：背景：斑点跟踪超声心动图（STE）衍生的参数可能比组织多普勒衍生的参数与左心室（LV）舒张和充盈压力具有更好的相关性。然而，尚未阐明哪个参数–应变或应变率–以及心肌变形的哪个方向–纵向或圆周–是左室松弛和充盈压的最有用标志。方法和结果：我们进行了一项前瞻性多中心研究，比较了77例患者的组织多普勒和STE衍生参数与LV压力衰减（τ）和LV平均舒张压（MDP）的时间常数的相关性。舒张早期二尖瓣环速度（e'）与τ的相关性较弱（r =？0.32，P <0.01），峰值纵向应变（LS）的相关性最强（r =？0.45，P <0.001）在STE衍生的参数中。 LVMDP与舒张早期流入速度（E）与e'（E / e'）之比之间存在适度的相关性（r = 0.50，P <0.001）。相反，E与LS的比率（E / LS）与LVMDP密切相关（r = 0.70，P <0.001）。 E / LS与LVMDP的相关性明显优于E / e'（P <0.01）。接收器工作特性分析表明，E / LS在曲线下面积最大，可以区分升高的LVMDP（E / LS 0.86，E / e'0.74，E / A 0.67）。结论：STE衍生的纵向参数与LV松弛和充盈压紧密相关。特别地，对于估计LV填充压力，E / LS可以比E / e'更准确。 （Circ J 2016; 80：1163-1170）

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