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首页> 外文期刊>Circulation journal >Lipocalin-Type Prostaglandin D Synthase Is Associated With Coronary Vasospasm and Vasomotor Reactivity in Response to Acetylcholine
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Lipocalin-Type Prostaglandin D Synthase Is Associated With Coronary Vasospasm and Vasomotor Reactivity in Response to Acetylcholine

机译：脂蛋白素型前列腺素D合酶与冠状动脉痉挛和对乙酰胆碱反应的血管舒缩反应性相关

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Background: ?Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the biosynthesis of PGD2, which acts as an anticoagulant, vasodilator, and inflammatory mediator. We examined the serum L-PGDS level, coronary macro- and microvasomotor functions, and their relationship in patients with chest pain and angiographically normal coronary arteries. Methods and Results: ?The study included 96 patients who underwent diagnostic coronary angiography and had angiographically normal coronary arteries. Blood flow of the left anterior descending coronary artery (LAD) was analyzed by Doppler guidewire examination. Serum L-PGDS level was determined by ELISA. Infusion of acetylcholine (ACh) induced vasospasm of the LAD in all patients with vasospastic angina (VSA) (n=45), but in none of the patients without VSA (n=51). There were no significant differences in the baseline clinical characteristics of the nonVSA and VSA groups, except for the frequency of smoking. Serum L-PGDS level in the VSA group was significantly higher than that in the nonVSA group (77.1±4.4 vs. 63.9±2.5μg/dl, P
机译：背景：脂环素型前列腺素D合酶（L-PGDS）催化PGD 2 的生物合成，PGD 2 可以作为抗凝剂，血管扩张剂和炎症介质。我们检查了患有胸痛和冠状动脉造影正常的患者的血清L-PGDS水平，冠状动脉宏观和微血管舒缩功能，以及它们之间的关系。方法和结果：这项研究包括96例接受了诊断性冠状动脉造影并且冠状动脉造影正常的患者。通过多普勒导丝检查分析左冠状动脉前降支（LAD）的血流。通过ELISA测定血清L-PGDS水平。在所有患有血管痉挛性心绞痛（VSA）的患者中（n = 45）输注乙酰胆碱（ACh）可以诱发LAD的血管痉挛（n = 45），但没有一个患者未注射VSA（n = 51）。除了吸烟频率外，nonVSA和VSA组的基线临床特征没有显着差异。 VSA组的血清L-PGDS水平显着高于非VSA组（77.1±4.4 vs. 63.9±2.5μg/ dl，P

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