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首页> 外文期刊>Circulation journal >Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –
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Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

机译：左心室非紧实患者心脏磁共振与天然T1映射对紧凑型心肌异常的特征–与晚期Ga增强的比较–

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Background: Native T1 mapping is an emerging cardiac magnetic resonance technique for quantitative evaluation of cardiomyopathies. This study aimed to investigate the usefulness of native T1 mapping in characterizing myocardial abnormalities in left ventricular non-compaction (LVNC) by comparing it with late gadolinium enhancement (LGE). Methods?and?Results: The study group of 31 LVNC patients and 8 normal controls underwent cardiovascular magnetic resonance to acquire the native T1 maps and LGE images. Of the 31 LVNC patients, 14 had LGE. The mean native T1 value of the normal controls, LGE(?) and LGE(+) patients was 1,098.8±40.8 ms, 1140.6±32.8 ms, and 1181.4±53.7 ms, respectively. Significant differences were found in native T1 between any 2 groups (F=9.74, P<0.001). In discriminating the presence of LGE in LVNC patients, the odds ratio and corresponding 95% confidence interval (CI) of native T1 were, respectively, 2.966 (95% CI: 1.123–7.835, P=0.028) and 4.348 (95% CI: 1.155–16.363, P=0.030) before and after adjusting for confounding factors with an increment of 1 standard deviation. Conclusions: The finding that LGE(?) patients had elevated native T1 compared with normal controls suggested native T1 mapping can be used earlier than LGE imaging to detect myocardial fibrosis in LVNC patients. Furthermore, higher native T1 values in LGE(+) patients than in the LGE(?) group suggested native T1 mapping is more sensitive than LGE imaging for identifying myocardial fibrosis in LVNC patients. ( Circ J 2016; 80: 1210–1216)
机译：背景：天然T1映射是一种新兴的心脏磁共振技术，用于定量评估心肌病。本研究旨在通过将天然T1映射与晚期L增强（LGE）进行比较来研究天然T1映射在表征左心室非紧致（LVNC）心肌异常中的有用性。方法和结果：研究组31例LVNC患者和8例正常对照者进行了心血管磁共振检查，以获取原始的T1图和LGE图像。在31例LVNC患者中，有14例患有LGE。正常对照组，LGE（α）和LGE（+）患者的平均天然T1值分别为1,098.8±40.8 ms，1140.6±32.8 ms和1181.4±53.7 ms。在任意两组之间的天然T1中发现显着差异（F = 9.74，P <0.001）。在区分LVNC患者中是否存在LGE时，天然T1的优势比和相应的95％置信区间（CI）分别为2.966（95％CI：1.123–7.835，P = 0.028）和4.348（95％CI： 1.155 – 16.63，P = 0.030）调整混杂因子前后的误差为1标准偏差。结论：LGE（？）患者的天然T1与正常对照相比升高的发现表明，天然T1映射可比LGE成像更早地用于检测LVNC患者的心肌纤维化。此外，LGE（+）患者的天然T1值比LGE（β）组更高，这表明在确定LVNC患者的心肌纤维化方面，天然T1映射比LGE成像更灵敏。 （2016年Circ J; 80：1210–1216）

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