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首页> 外文期刊>Circulation journal >Systemic Inflammation Is Associated With Coronary Artery Calcification and All-Cause Mortality in Chronic Kidney Disease
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Systemic Inflammation Is Associated With Coronary Artery Calcification and All-Cause Mortality in Chronic Kidney Disease

机译：全身性炎症与慢性肾脏疾病的冠状动脉钙化和全因死亡率相关

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Background: Presence of systemic inflammation in chronic kidney disease (CKD) is associated with advanced coronary artery calcification (CAC). The prognostic significance of this association, however, is unknown. We evaluated the associations between CAC, estimated glomerular filtration rate (eGFR) and all-cause mortality, to determine whether the associations differ according to the presence of systemic inflammation. Methods?and?Results: We followed 30,703 consecutive individuals who underwent CAC measurement for a median of 79 months (IQR, 65–96 months). Patients were categorized according to baseline CAC score (0, 1–99, 100–399 and ≥400), eGFR (2) and high-sensitivity C-reactive protein (hsCRP; 2) only in those with higher hsCRP. Conclusions: Patients with low eGFR and more extensive CAC had greater risk of mortality, and associations differed according to the presence of systemic inflammation. Among the CKD patients, coronary evaluation may be considered for those with elevated hsCRP. ( Circ J 2016; 80: 1644–1652)
机译：背景：慢性肾脏病（CKD）中全身炎症的存在与冠状动脉钙化（CAC）有关。然而，这种关联的预后意义尚不清楚。我们评估了CAC，估计的肾小球滤过率（eGFR）和全因死亡率之间的关联，以确定关联是否根据全身性炎症的存在而不同。方法和结果：我们追踪了30,703名连续的个体，他们接受了CAC测量，中位数为79个月（IQR，65-96个月）。仅根据基线CAC评分（0、1–99、100–399和≥400），eGFR（2 ）和高敏C反应蛋白（hsCRP; 2 ）对患者进行分类。 hsCRP较高的人。结论：eGFR较低且CAC范围更广的患者有更高的死亡风险，并且根据全身性炎症的存在而有所不同。在CKD患者中，可以考虑对hsCRP升高的患者进行冠状动脉评估。 （Circ J 2016; 80：1644–1652）

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