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首页> 外文期刊>Circulation journal >Association of Serum Triglycerides With Arterial Stiffness in Subjects With Low Levels of Low-Density Lipoprotein Cholesterol
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Association of Serum Triglycerides With Arterial Stiffness in Subjects With Low Levels of Low-Density Lipoprotein Cholesterol

机译：低密度脂蛋白胆固醇水平低的受试者血清甘油三酸酯与动脉僵硬度的关系

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Background: The independent role of serum triglyceride (TG) levels as a cardiovascular risk factor is still not elucidated. We aimed to investigate if the effect of TG on arterial stiffness is influenced by the serum level of low-density lipoprotein cholesterol (LDL-C). Methods?and?Results: We studied 11,640 subjects who underwent health checkups. They were stratified into 4 groups according to LDL-C level (≤79, 80–119, 120–159, and ≥160 mg/dL). Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). In each group, univariate and multivariete logistic regression analyses were performed to investigate the association between high TG (≥150 mg/dL) and high baPWV (1,400 cm/s). In the univarite analysis, high TG was significantly associated with high baPWV in LDL-C 79 mg/dL (OR, 3.611, 95% CI, 2.475–5.337; P0.0001) and 80–119 mg/dL (OR, 1.881; 95% CI, 1.602–2.210; P0.0001), but not in LDL-C 120–159 mg/dL and ≥160 mg/dL. In the multivariate analysis, high TG was significantly associated with high baPWV in LDL-C ≤79 mg/dL (OR, 2.558; 95% CI, 1.348–4.914; P=0.0040) and LDL-C 80–119 mg/dL (OR, 1.677; 95% CI, 1.315–2.140; P0.0001), but not in LDL-C 120–159 mg/dL and ≥160 mg/dL. Conclusions: High TG and increased arterial stiffness showed an independent relationship in a Japanese general population with LDL-C ≤119 mg/dL. TG-lowering therapy might be an additional therapeutic consideration in these subjects.
机译：背景：尚不清楚血清甘油三酸酯（TG）水平作为心血管危险因素的独立作用。我们旨在研究TG对动脉僵硬度的影响是否受血清低密度脂蛋白胆固醇（LDL-C）的影响。方法和结果：我们研究了11,640名接受健康检查的对象。根据低密度脂蛋白胆固醇水平将它们分为4组（≤79、80–119、120–159和≥160mg / dL）。通过肱-踝脉搏波速度（baPWV）评估动脉僵硬度。在每组中，进行单因素和多因素logistic回归分析，以研究高TG（≥150mg / dL）和高baPWV（> 1,400 cm / s）之间的关系。在univarite分析中，在LDL-C <79 mg / dL（OR，3.611，95％CI，2.475–5.337; P <0.0001）和80–119 mg / dL（OR，1.881）下，高TG与高baPWV显着相关; 95％CI，1.602–2.210; P <0.0001），但在LDL-C 120–159 mg / dL和≥160mg / dL中没有。在多变量分析中，LDL-C≤79mg / dL（OR，2.558; 95％CI，1.348–4.914; P = 0.0040）和LDL-C 80-119 mg / dL（TG，高TG与高baPWV显着相关。或，1.677; 95％CI，1.315–2.140; P <0.0001），但在LDL-C 120–159 mg / dL和≥160mg / dL中没有。结论：在日本LDL-C≤119 mg / dL的普通人群中，高TG和动脉僵硬程度呈独立关系。在这些受试者中，降低TG的治疗可能是另外的治疗考虑。

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