• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Circulation journal >Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor γ and δ in Vascular Diseases
【24h】

Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor γ and δ in Vascular Diseases

机译：过氧化物酶体增殖物激活的受体γ和δ在血管疾病中的多效性作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Peroxisome proliferator-activated receptors gamma (PPARγ) and delta (PPARδ) are nuclear receptors that have significant physiological effects on glucose and lipid metabolism. Experimental studies in animal models of metabolic disease have demonstrated their effects on improving lipid profile, insulin sensitivity, and reducing inflammatory responses. PPARγ and -δ are also expressed in the vasculature and their beneficial effects have been examined in various cardiovascular disease models such as atherosclerosis, hypertension, diabetic vascular complications, etc. using pharmacological ligands or genetic tools including viral vectors and transgenic mice. These studies suggest that PPARγ and δ are antiinflammatory, antiatherogenic, antioxidant, and antifibrotic against vascular diseases. Several signaling pathways, effector molecules, as well as coactivators/repressors have been identified as responsible for the protective effects of PPARγ and -δ in the vasculature. We discuss the pleiotropic effect of PPARγ and δ in vascular dysfunction, including atherosclerosis, hypertension, vascular remodeling, vascular injury, and diabetic vasculopathy, in various animal models, and the major underlying mechanisms. We also compare the phenotypes of several endothelial cell/vascular smooth muscle-specific PPARγ and -δ knockout and overexpressing transgenic mice in various disease models, and the implications underlying the functional importance of vascular PPARγ and δ in regulating whole-body homeostasis.??( Circ J ?2013; 77: 2664–2671)
机译：过氧化物酶体增殖物激活受体γ（PPARγ）和δ（PPARδ）是核受体，对葡萄糖和脂质代谢具有重要的生理作用。在代谢性疾病动物模型中进行的实验研究表明，它们可改善脂质分布，改善胰岛素敏感性并减少炎症反应。 PPARγ和-δ也在脉管系统中表达，并已使用药理配体或遗传工具（包括病毒载体和转基因小鼠）在各种心血管疾病模型（如动脉粥样硬化，高血压，糖尿病性血管并发症等）中检查了它们的有益作用。这些研究表明，PPARγ和δ具有抗炎，抗动脉粥样硬化，抗氧化剂和抗血管疾病的抗纤维化作用。已经确定了几种信号传导途径，效应分子以及共激活因子/阻遏因子与PPARγ和-δ在脉管系统中的保护作用有关。我们讨论了在各种动物模型中PPARγ和δ对血管功能障碍的多效性作用，包括动脉粥样硬化，高血压，血管重构，血管损伤和糖尿病性血管病变，以及主要的潜在机制。我们还比较了在各种疾病模型中几种内皮细胞/血管平滑肌特异性PPARγ和-δ基因敲除和过表达转基因小鼠的表型，以及血管PPARγ和δ在调节全身稳态中的功能重要性。 （Circ J？2013; 77：2664–2671）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号