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首页> 外文期刊>Circulation journal >Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker
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Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker

机译：低剂量氢氯噻嗪和血管紧张素II受体阻滞剂联合治疗的低盐摄入量和血清钠水平的变化

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Background: ?The present study was conducted to examine the association of dietary salt intake with changes in serum sodium (srNa) levels when angiotensin II receptor blocker (ARB) treatment is changed to the combination of ARB plus low-dose diuretic (hydrochlorothiazide [HCTZ]). Methods and Results: ?In 88 patients (age 70±12 years), ARB treatment was switched to the combination therapy (same dosage ARB+12.5mg/day HCTZ). The srNa level was measured before and 6 months after administration of the combination. The daily salt intake was estimated by the Kawasaki formula using second morning urine sample. The study subjects were divided into quintile ranges according to daily salt intake. The reduction in srNa levels by switching to the combination treatment was significant in subjects in the lowest quintile Q5 (≤8.9g/day salt intake), but not in those in Q1–4 (28.1–9.3g/day salt intake). Increases in serum creatinine and uric acid levels were significantly larger in the former group than in the latter group. Conclusions: ?In elderly Japanese subjects with low salt intake (
机译：背景：本研究旨在研究将血管紧张素II受体阻滞剂（ARB）治疗改为ARB加小剂量利尿剂（氢氯噻嗪[HCTZ]时，饮食盐摄入量与血清钠（srNa）水平变化的关系。 ]）。方法和结果：在88例患者（年龄70±12岁）中，将ARB治疗改为联合治疗（相同剂量的ARB + 12.5mg /天HCTZ）。在联合给药之前和之后6个月测量srNa水平。每天的盐摄入量是根据川崎公式使用第二天早晨的尿液样本估算的。根据每日的盐摄入量将研究对象分为五等分范围。在最低五分位数Q5（≤8.9g /天盐摄入量）的受试者中，转用联合治疗可显着降低srNa水平，而在1-4季度（28.1-9.3g /天盐摄入量）中则无此意义。前一组的血清肌酐和尿酸水平升高明显高于后一组。结论：在低盐摄入量的日本老年受试者中（

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