Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest – Prognostic Value of Combined Risk Factors –

Hideo Okamura; Tsukasa Kamakura; Hiroshi Morita; Koji Tokioka; Ikutaro Nakajima; Mitsuru Wada; Kohei Ishibashi; Koji Miyamoto; Takashi Noda; Takeshi Aiba; Nobuhiro Nishii; Satoshi Nagase; Wataru Shimizu; Satoshi Yasuda; Hisao Ogawa; Shiro Kamakura; Hiroshi Ito; Tohru Ohe; Kengo F. Kusano

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Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest – Prognostic Value of Combined Risk Factors –

机译：没有事先心脏骤停的Brugada综合征患者的风险分层–合并危险因素的预后价值–

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Background: Risk stratification in patients with Brugada syndrome for primary prevention of sudden cardiac death is still an unsettled issue. A recent consensus statement suggested the indication of implantable cardioverter defibrillator (ICD) depending on the clinical risk factors present (spontaneous type 1 Brugada electrocardiogram (ECG) [Sp1], history of syncope [syncope], and ventricular fibrillation during programmed electrical stimulation [PES+]). The indication of ICD for the majority of patients, however, remains unclear. Methods?and?Results: A total of 218 consecutive patients (211 male; aged 46±13 years) with a type 1 Brugada ECG without a history of cardiac arrest who underwent evaluation for ICD including electrophysiological testing were examined retrospectively. During a mean follow-up period of 78 months, 26 patients (12%) developed arrhythmic events. On Kaplan-Meier analysis patients with each of Sp1, syncope, or PES+ suffered arrhythmic events more frequently (P=0.018, P

机译：背景：用于初步预防心脏骤停的Brugada综合征患者的风险分层仍未解决。最近的共识性声明建议根据存在的临床风险因素（自发性1型Brugada心电图（ECG）[Sp1]，晕厥病史[晕厥]和程序性电刺激过程中的心室纤颤[PES + ]）。然而，大多数患者的ICD适应症仍不清楚。方法和结果：回顾性分析了连续218例无心跳骤停史的1型Brugada ECG连续患者（211例男性，年龄46±13岁），并对其进行了ICD评估，包括电生理检查。在平均78个月的随访期间，有26名患者（12％）出现了心律不齐事件。在Kaplan-Meier分析中，患有Sp1，晕厥或PES +的患者更常发生心律不齐事件（P = 0.018，P

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《Circulation journal》 |2015年第2期|共8页
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Hideo Okamura; Tsukasa Kamakura; Hiroshi Morita; Koji Tokioka; Ikutaro Nakajima; Mitsuru Wada; Kohei Ishibashi; Koji Miyamoto; Takashi Noda; Takeshi Aiba; Nobuhiro Nishii; Satoshi Nagase; Wataru Shimizu; Satoshi Yasuda; Hisao Ogawa; Shiro Kamakura; Hiroshi Ito; Tohru Ohe; Kengo F. Kusano;
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中图分类心脏、血管（循环系）疾病;
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1. Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest - Prognostic Value of Combined Risk Factors - [J] . Okamura Hideo, Kamakura Tsukasa, Morita Hiroshi, Circulation journal . 2015,第2期

机译：没有事先心脏骤停的Brugada综合征患者的风险分层-综合危险因素的预后价值-
2. Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest – Prognostic Value of Combined Risk Factors – [J] . Hideo Okamura, Tsukasa Kamakura, Hiroshi Morita, Circulation journal . 2015,第2期

机译：没有事先心脏骤停的Brugada综合征患者的风险分层–合并危险因素的预后价值–
3. Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: usefulness of a combined clinical and electrophysiologic approach. [J] . Delise P, Allocca G, Marras E, European Heart Journal: The Journal of the European Society of Cardiology . 2011,第2期

机译：在没有先前心脏骤停的情况下，患有Brugada 1型ECG模式的个体的风险分层：结合临床和电生理方法的有用性。
4. The importance of the charlson index in risk stratification in patients admitted for acute coronary syndrome without st-segment elevation [C] . Ramirez Marrero, Gaitan Roman, Jimenez Navarro, International Conference on Pre-hypertension Cardio Metabolic Syndrome . 2011

机译：Charlson指数在没有ST段高度的患者患者中患者风险分层的重要性
5. Early Risk Stratification of Patients After Resuscitation from Out-Of-Hospital Cardiac Arrest [D] . Drennan, Ian R. 2020

机译：从医院外卡骤停的复苏后早期风险分层
6. Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: usefulness of a combined clinical and electrophysiologic approach [O] . Pietro Delise, Giuseppe Allocca, Elena Marras, -1

机译：没有先前心脏骤停的Brugada 1型心电图模式患者的风险分层：临床和电生理学联合治疗方法的实用性
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Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest – Prognostic Value of Combined Risk Factors –

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